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Ozone-related acute excess mortality projected to increase in the absence of cl...

Domingo, NGG; Fiore, AM; Lamarque, J-F; Kinney, PL; Jiang, L; Gasparrini, A; Breitner, S; Lavigne, E; Madureira, J; Masselot, P; Silva, SDNPD

Short-term exposure to ground-level ozone in cities is associated with increased mortality and is expected to worsen with climate and emission changes. However, no study has yet comprehensively assessed future ozone-related acute mortality across diverse geographic areas, various climate scenarios, and using CMIP6 multi-model ensembles, limiting our knowledge on future changes in global ozone-related acute mort...


Fluctuating risk of acute kidney injury-related mortality for four weeks after ...

Min, J; Kang, D-H; Kang, C; Bell, ML; Kim, H; Yang, J; Gasparrini, A; Lavigne, E; Hashizume, M; Kim, Y; Fook Sheng Ng, C; Honda, Y; Pereira da Silva, SN

Background: Recent studies have reported that air pollution is related to kidney diseases. However, the global evidence on the risk of death from acute kidney injury (AKI) owing to air pollution is limited. Therefore, we investigated the association between short-term exposure to air pollution—particulate matter ≤ 2.5 μm (PM2.5), ozone (O3), and nitrogen dioxide (NO2)—and AKI-related mortality using a multi-cou...


Air pollution mixture complexity and its effect on PM2.5-related mortality: A m...

Masselot, P; Kan, H; Kharol, SK; Bell, ML; Sera, F; Lavigne, E; Breitner, S; Das Neves Pereira Da Silva, S; Burnett, RT; Gasparrini, A; Brook, JR

Background: Fine particulate matter (PM2.5) occurs within a mixture of other pollutant gases that interact and impact its composition and toxicity. To characterize the local toxicity of PM2.5, it is useful to have an index that accounts for the whole pollutant mix, including gaseous pollutants. We consider a recently proposed pollutant mixture complexity index (PMCI) to evaluate to which extent it relates to PM...


Temporal variations in the short-term effects of ambient air pollution on cardi...

Schwarz, M; Peters, A; Stafoggia, M; de'Donato, F; Sera, F; Bell, ML; Guo, Y; Honda, Y; Huber, V; Jaakkola, JJK; Urban, A; Vicedo-Cabrera, AM

Background: Ambient air pollution, including particulate matter (such as PM10 and PM2·5) and nitrogen dioxide (NO2), has been linked to increases in mortality. Whether populations’ vulnerability to these pollutants has changed over time is unclear, and studies on this topic do not include multicountry analysis. We evaluated whether changes in exposure to air pollutants were associated with changes in mortality ...


Regional variation in the role of humidity on city-level heat-related mortality

Guo, Q; Mistry, MN; Zhou, X; Zhao, G; Kino, K; Wen, B; Cvijanovic, I; Yoshimura, K; Satoh, Y; Kim, Y; Ng, CFS; Vicedo-Cabrera, AM; Armstrong, B

The rising humid heat is regarded as a severe threat to human survivability, but the proper integration of humid heat into heat-health alerts is still being explored. Using state-of-the-art epidemiological and climatological datasets, we examined the association between multiple heat stress indicators (HSIs) and daily human mortality in 739 cities worldwide. Notable differences were observed in the long-term tr...


Interactive effects of ambient fine particulate matter and ozone on daily morta...

Liu, C; Chen, R; Sera, F; Vicedo-Cabrera, AM; Guo, Y; Tong, S; Lavigne, E; Correa, PM; Ortega, NV; Achilleos, S; Roye, D; Jaakkola, JJ; Ryti, N

Objective To investigate potential interactive effects of fine particulate matter (PM2.5) and ozone (O3) on daily mortality at global level. Design Two stage time series analysis. Setting 372 cities across 19 countries and regions. Population Daily counts of deaths from all causes, cardiovascular disease, and respiratory disease. Main outcome measure Daily mortality data during 1994-2020. Stratified analyses by...


Short-Term Association between Sulfur Dioxide and Mortality: A Multicountry Ana...

O'Brien, E; Masselot, P; Sera, F; Roye, D; Breitner, S; Ng, CFS; Coelho, MDZS; Madureira, J; Tobias, A; Vicedo-Cabrera, AM; Bell, ML; Lavigne, E

BACKGROUND: Epidemiological evidence on the health risks of sulfur dioxide (SO2) is more limited compared with other pollutants, and doubts remain on several aspects, such as the form of the exposure-response relationship, the potential role of copollutants, as well as the actual risk at low concentrations and possible temporal variation in risks.OBJECTIVES: Our aim was to assess the short-term association betw...


Global short-term mortality risk and burden associated with tropical cyclones f...

Huang, WZ; Li, SS; Vogt, T; Xu, RB; Tong, SL; Molina, T; Masselot, P; Gasparrini, A; Armstrong, B; Pascal, M; Royé, D; Ng, CFS; Vicedo-Cabrera, AM

Background The global spatiotemporal pattern of mortality risk and burden attributable to tropical cyclones is unclear. We aimed to evaluate the global short-term mortality risk and burden associated with tropical cyclones from 1980 to 2019.Methods The wind speed associated with cyclones from 1980 to 2019 was estimated globally through a parametric wind field model at a grid resolution of 0 & BULL;5 & DEG;x 0 &...


Differential Mortality Risks Associated With PM2.5 Components A Multi-Country, ...

Masselot, P; Sera, F; Schneider, R; Kan, H; Lavigne, É; Stafoggia, M; Tobias, A; Chen, H; Burnett, RT; Schwartz, J; Zanobetti, A; Bell, ML; Chen, B-Y

Background: The association between fine particulate matter (PM2.5) and mortality widely differs between as well as within countries. Differences in PM2.5 composition can play a role in modifying the effect estimates, but there is little evidence about which components have higher impacts on mortality. Methods: We applied a 2-stage analysis on data collected from 210 locations in 16 countries. In the first stag...


Comparison of weather station and climate reanalysis data for modelling tempera...

Mistry, MN; Schneider, R; Masselot, P; Royé, D; Armstrong, B; Kyselý, J; Orru, H; Sera, F; Tong, S; Lavigne, É; Urban, A; Madureira, J; García-León, D

Epidemiological analyses of health risks associated with non-optimal temperature are traditionally based on ground observations from weather stations that offer limited spatial and temporal coverage. Climate reanalysis represents an alternative option that provide complete spatio-temporal exposure coverage, and yet are to be systematically explored for their suitability in assessing temperature-related health r...


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