9 documents found, page 1 of 1
Editorial: Exploring molecular recognition: integrating experimental and comput...
Matamá, Maria Teresa Gonçalves Macedo; Rego, António MIguel Araújo; Wang, Junmei; Castro, Tarsila GabrielEditorial on the Research Topic Exploring molecular recognition: integrating experimental and computational approaches
Changing human hair fibre colour and shape from the follicle
Matamá, Maria Teresa Gonçalves Macedo; Costa, Cristiana Filipa Chaves; Fernandes, Bruno; Araújo, Rita; Cruz, Célia F.; Tortosa, FranciscoIntroduction: Natural hair curvature and colour are genetically determined human traits, that we inten tionally change by applying thermal and chemical treatments to the fibre. Presently, those cosmetic methodologies act externally and their recurrent use is quite detrimental to hair fibre quality and even to our health. Objectives: This work represents a disruptive concept to modify natural hair colour and cur...
Novel keratin-based particles encapsulating essential oils: a step towards deve...
Fernandes, Mariana P.; Matamá, Maria Teresa Gonçalves Macedo; Noro, Jennifer Martins; Costa, André F.; Silva, Carla; Fernandes-Ferreira, ManuelEssential oils (EOs) are playing a pivotal role in pest control within biologic farming due to their botanical origin and potential as biocontrol agents. However, their use is still limited by challenges like high volatility, rapid oxidation, and susceptibility to degradation in field conditions. Additionally, EOs might present some health risks to humans through inhalation or direct contact during application....
A comprehensive review of mammalian pigmentation: paving the way for innovative...
Fernandes, Bruno Pacheco; Cavaco-Paulo, Artur; Matamá, Maria Teresa Gonçalves MacedoThe natural colour of hair shafts is formed at the bulb of hair follicles, and it is coupled to the hair growth cycle. Three critical processes must happen for efficient pigmentation: (1) melanosome biogenesis in neural crest-derived melanocytes, (2) the biochemical synthesis of melanins (melanogenesis) inside melanosomes, and (3) the transfer of melanin granules to surrounding pre-cortical keratinocytes for th...
Transforming second-generation ethanol production waste into sustainable enzyma...
Polesso, Camila Borges; Fontana, Roselei Claudete; Costa, Cristiana C.; Fernandes, Bruno; Matamá, Maria Teresa Gonçalves Macedo; Cavaco-Paulo, ArturAgro-industrial residues were used as a successful, cheap and renewable substrate, capable of increasing activity of ligninolytic enzymes for further use in melanin degradation assays to develop inputs for the treatment of skin hyperpigmentation. The analysis of melanin degradation was performed in a quantitative and qualitative way. The enzymatic crude broth extract, rich in laccases, produced by Marasmiellus ...
The structural properties of odorants modulate their association to human odora...
Castro, Tarsila Gabriel; Silva, C.; Matamá, Maria Teresa Gonçalves Macedo; Cavaco-Paulo, ArturThe binding of known odorant molecules to the human odorant-binding protein (hOBP) was evaluated in silico. Docking experiments elucidate the preferable binding site and binding affinity of odorant molecules to hOBP. The physicochemical properties molecular weight (MW), vapor pressure (Vp), hydrophobicity level (logP), number of double bonds (NºDB), degree of unsaturation (DoU) and the chemical classification, ...
Comparing the delivery to the hair bulb of two fluorescent molecules of distinc...
Costa, Cristiana; Fernandes, Bruno Pacheco; Guimarães, Diana Isabel Pereira; Nogueira, Eugénia; Martins, Madalena; Matamá, Maria Teresa Gonçalves MacedoThe follicular route is an important drug penetration pathway in any topical application, either concerning dermatological and cosmetic skin treatments or any transdermal administration regimen. Efficient transport into follicles will depend on drug inherent properties but also on the chosen vehicle. The main study goal was to compare several systems for the delivery to the hair bulb of two fluorescent molecule...
Biological response of Ti-based intermetallic thin films, to be used as biopote...
Lopes, Cláudia Jesus Ribeiro; Gonçalves, Víctor; Costa, R.; Coffineau, Dorian; Borges, Joel; Rodrigues, Marco S.; Gomes, Andreia CBiopotential electrodes are crucial in modern preventive medicine, being the primarily responsible for the high-resolution monitoring of the bioelectrical activity of in human body. In this work, flexible dry biopotential electrodes based on binary systems of Ti-Me (Me = Al, Cu, Ag, Au) thin films were developed for non-invasive physiological monitoring. These biopotential electrodes supported by polymeric base...
Cellulose biomodification with cutinase fusion proteins
Matamá, Maria Teresa Gonçalves Macedo; Cavaco-Paulo, ArturThe textile industry presents well succeed examples of enzyme applications on the processing of natural fi bres. The design of hybrid enzymes mimics the strategies that Nature uses to evolve and it is a powerful tool in biotechnology. The production and application of the cutinase fused to carbohydrate - binding modules (CBMs) has provided strong evidences of bei ng an interesting strategy to pursuit. The CBMs ...