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Severe Hypercapnia and Outcome of Mechanically Ventilated Patients with Moderat...

Nin, N; Muriel, A; Peñuelas, O; Brochard, L; Lorente, JA; Ferguson, N; Raymondos, K; Ríos, F; Violi, DA; Thille, A; González, M; Villagomez, AJ

PURPOSE: To analyze the relationship between hypercapnia developing within the first 48 h after the start of mechanical ventilation and outcome in patients with acute respiratory distress syndrome (ARDS). PATIENTS AND METHODS: We performed a secondary analysis of three prospective non-interventional cohort studies focusing on ARDS patients from 927 intensive care units (ICUs) in 40 countries. These patients rec...


Association Between Ventilatory Settings and Development of Acute Respiratory D...

Tejerina, E; Pelosi, P; Muriel, A; Peñuelas, O; Sutherasan, Y; Frutos-Vivar, F; Nin, N; Davies, AR; Rios, F; Violi, DA; Raymondos, K; Hurtado, J

PURPOSE: In neurologically critically ill patients with mechanical ventilation (MV), the development of acute respiratory distress syndrome (ARDS) is a major contributor to morbidity and mortality, but the role of ventilatory management has been scarcely evaluated. We evaluate the association of tidal volume, level of PEEP and driving pressure with the development of ARDS in a population of patients with brain ...


Outcome of mechanically ventilated patients who require a tracheostomy

Frutos-Vivar, F; Esteban, A; Apezteguía, C; Anzueto, A; Nightingale, P; González, M; Soto, L; Rodrigo, C; Raad, J; David, C; Matamis, D; D'Empaire, G

OBJECTIVE: To estimate the prevalence of, the risk factors associated with, and the outcome of tracheostomy in a heterogeneous population of mechanically ventilated patients. DESIGN: Prospective, observational cohort study. SETTING: A total of 361 intensive care units from 12 countries. PATIENTS: A cohort of 5,081 patients mechanically ventilated for >12 hrs. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: ...


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