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Bilateral Internuclear Ophthalmoplegia: Multiple Sclerosis rather Myelin Oligod...
Marques, Ana João; Matas, Andreia; Gabriel, João PauloIncreasing knowledge about neuro-inflammatory conditions as lead to new challenges in establishing a diagnosis. Clinical distinctive features might help. We present a 34-year-old patient with bilateral internuclear ophthalmoplegia (bINO). Investigation was compatible with demyelinating central nervous system (CNS) disease. Low-positive IgG myelin oligodendrocyte glycoprotein (MOG) antibodies were found. Rituxim...
Creutzfeldt-Jakob Disease: A Decade of Assistential Activity at Centro Hospital...
Marques, Ana João; Mendes, Michel; Carvalho, Andreia; Almendra, Ricardo; Matas, Andreia; Veiga, Andreia; Guimarães, Pedro; Velon, Ana GraçaIntroduction: Sporadic Creutzfeldt-Jakob disease (sCJD) is the most frequent of human prion diseases, with an estimated incidence of 1 case per million / habitants per year. Clinical manifestations include multidomain cognitive impairment with pyramidal, extrapyramidal and/or cerebellar signs. It is a rapidly progressive and fatal disease. Our aim was to do a sociodemographic, clinical and progression evaluatio...
Charcot-Marie-Tooth Type 2 Disease and Relapsing Remitting Multiple Sclerosis C...
Marques, Ana João; Matas, Andreia; Veiga, Andreia; Gabriel, João PauloMultiple sclerosis (MS) and Charcot-Marie-Tooth disease (CMT) association has been reported, namely in CMTX and CMT1A. A 37-year-old woman with CMT type 2 (MFN2 mutation) developed subacute brainstem syndrome (left internuclear ophthalmoplegia, facial palsy and ataxia). Brain magnetic resonance imaging revealed infratentorial, periventricular and subcortical lesions, typical of MS (positive CSF oligoclonal band...
InMS: chronic insomnia disorder in multiple sclerosis – a portuguese multicentr...
Viana, Pedro; Rodrigues, Elisabete; Fernandes, Carina; Matas, Andreia; Barreto, Rui; Mendonça, Marcelo; Peralta, Ana; Geraldes, RuthBackground: Sleep may be disrupted in Multiple Sclerosis (MS), but the prevalence of chronic insomnia disorder (CID) using standard diagnostic criteria is unknown. Objectives: To determine the prevalence of CID in an MS population, the frequency of CID subtypes, associated factors and impact on quality of life (QoL). Methods: Multicentre, hospital-based cross-sectional study. An adapted version of the Brief Ins...