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Erasmus Syndrome: an Underrecognized Entity

Magalhães, A; Moreira, I; Pinheiro, S; Borba, A

We present a case of a 33-year-old male who worked as a plumber and a locksmith. The patient presented with diffuse myalgia and asthenia, skin sclerosis and puffy fingers, Raynaud's phenomenon, exertional dyspnea and erectile dysfunction. The presence of specific autoantibodies enabled the diagnosis of systemic sclerosis. Chest-computed tomography revealed upper lobe consolidation. After extensive evaluation, t...


NEXTSTEP - Developing future smart secondary substations

Carreira, PJG; Santos, JMM; Pires, L; Ferreira, VGM; Almeno, L; Pinheiro, S; Neves, E; Azevedo, L; Costa, N; Gomes, F; Gouveia, C; Zanghi, E; Pereira, J


Multimodality Imaging in Connective Tissue Disease-Related Interstitial Lung Di...

Ruano, C; Grafino, M; Borba, A; Pinheiro, S; Fernandes, O; Silva, S; Bilhim, T; Moraes-Fontes, MF; Irion, K

Interstitial lung disease is a well-recognised manifestation and a major cause of morbidity and mortality in patients with connective tissue diseases. Interstitial lung disease may arise in the context of an established connective tissue disease or be the initial manifestation of an otherwise occult autoimmune disorder. Early detection and characterisation are paramount for adequate patient management and requi...


Limbic Encephalitis When the Immune Response Is the Hidden Problem

Amaral, M; Ferrão, J; Duarte, B; Pinheiro, S

Limbic Encephalitis (LE) defined as a rare and frequently underrecognized immunomediated syndrome, presents with a constellation of unspecific behavioral and neuropsychiatric symptoms, developing over weeks to months. Personality disturbance, complex partial mesotemporal seizures and a subacute severe impairment of short-term memory are the cardinal symptoms, reflecting the involvement of the grand lobe limbiqu...


Catatonia in Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis Misdiagnose...

Ponte, A; Brito, A; Nóbrega, C; Pinheiro, S; Gama Marques, J

Anti-N-Mmethyl-D-aspartate receptor encephalitis is an autoimmune disease of the central nervous system with prominent neurologic and psychiatric features. Symptoms appear progressively and sometimes with an exclusively psychiatric initial presentation. The patient's evaluation should be meticulous, and we should use all the diagnostic tests required for the exclusion of entities that can mimic this disease. We...



Ocular Involvement in Systemic Lupus Erythematosus Patients: a Paradigm Shift B...

Dias-Santos, A; Ferreira, J; Pinheiro, S; Cunha, JP; Alves, M; Papoila, AL; Moraes-Fontes, MF; Proença, R

Objective: To evaluate ocular involvement in a cohort of systemic lupus erythematosus (SLE) patients of a tertiary referral center and to compare the results with the existing literature. Methods: Patients underwent a complete ophthalmological evaluation, including visual acuity, slit-lamp examination, fluorescein staining, Schirmer-I test, Goldmann applanation tonometry, fundoscopy, 10-2 automated threshold vi...


The Role of Ophthalmic Imaging in Central Nervous System Degeneration in System...

Dias-Santos, A; Proença, R; Tavares Ferreira, J; Pinheiro, S; Cunha, JP; Proença, R; Moraes-Fontes, MF

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder that can involve any organ system. Central nervous system involvement can be a severe life threatening complication, ultimately resulting in severe neurodegenerative changes. Magnetic resonance imaging suggests that neurodegeneration, which may have deleterious effects on brain function, may occur early in SLE and experimental models...



Ultrasound Detects Subclinical Joint Inflammation in the Hands and Wrists of Pa...

Ruano, C; Malheiro, R; Oliveira, JF; Pinheiro, S; Vieira, LS; Moraes-Fontes, MF

OBJECTIVES: To assess the prevalence and severity of ultrasonographic abnormalities of the hand and wrist of asymptomatic patients with systemic lupus erythematosus (SLE) and compare these findings with those from patients with SLE with musculoskeletal signs or symptoms and healthy controls. METHODS: We conducted a prospective cross-sectional study that evaluated bilaterally, with grey-scale and power Doppler (...


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