11 documents found, page 1 of 2

Vigilância a Longo Prazo na Gestão do Cancro da Próstata: Factos e Armadilhas

DIAGNOSTIC APPROACH TO ARTERIAL HYPERTENSION OF SUSPECTED SECONDARY CAUSE IN PR...

Renal pathology is one of the leading causes of secondary arterial hypertension. Hypertension of a renal cause can originate in the renal parenchyma or the renal artery and is called renal parenchymal hypertension or renovascular hypertension, respectively. The presence of hypertension is common in kidney diseases, being a critical prognostic factor, so its diagnosis, treatment and adequate guidance are essenti...

DIAGNOSTIC APPROACH TO ARTERIAL HYPERTENSION OF SUSPECTED SECONDARY CAUSE IN PR...

Secondary Arterial Hypertension (AHT) is responsible for 5 to 10% of all cases of AHT and presents increased morbimortality when compared to primary AHT. Secondary AHT stems from a diverse group of medical conditions, which are potentially reversible, or even curable, through specific management approaches. The potential to effectively reverse this group of diseases and, by consequence, the associated AHT accou...

DIAGNOSTIC APPROACH TO ARTERIAL HYPERTENSION OF SUSPECTED SECONDARY CAUSE IN PR...

Endocrine diseases are frequent causes of secondary hypertension, and primary hyperaldosteronism is the most common endocrine cause of hypertension. Unlike other endocrine diseases, primary hyperaldosteronism has no typical phenotypic characteristics, and is often misdiagnosed as essential hypertension. It is, however, associated with much higher morbidity and mortality than essential hypertension. Targeted the...

Iron Skin Staining: A Rare but Permanent Complication Following IV Iron Infusion

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Valuing Mundane Manifestations of Rare, but Underdiagnosed, Diseases in Portuga...

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StressMatic: a novel automated system to induce depressive- and anxiety-like ph...

Major depressive disorder (MDD) is a multidimensional psychiatric disorder that is estimated to affect around 350 million people worldwide. Generating valid and effective animal models of depression is critical and has been challenging for neuroscience researchers. For preclinical studies, models based on stress exposure, such as unpredictable chronic mild stress (uCMS), are amongst the most reliable and used, ...

Beyond new neurons in the adult hippocampus: imipramine acts as a pro-astroglio...

Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, l...

Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes a...

The transcription factor activating protein two gamma (AP2γ) is an important regulator of neurogenesis both during embryonic development as well as in the postnatal brain, but its role for neurophysiology and behavior at distinct postnatal periods is still unclear. In this work, we explored the neurogenic, behavioral, and functional impact of a constitutive and heterozygous AP2γ deletion in mice from early post...

Cell cycle regulation of hippocampal progenitor cells in experimental models of...

Changes in adult hippocampal cell proliferation and genesis have been largely implicated in depression and antidepressant action, though surprisingly, the underlying cell cycle mechanisms are largely undisclosed. Using both an <i>in vivo</i> unpredictable chronic mild stress (uCMS) rat model of depression and <i>in vitro</i> rat hippocampal-derived neurosphere culture approaches, we aimed to unravel the cell cy...