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Diagnosis of COVID-19 by sound-based analysis of vocal recordings
Carreiro Martins, Pedro; Paixão, P.; Caires, Iolanda; Rodrigues, A.; Matias, P.; Gamboa, H.; Carreiro, A.; Soares, F.; Gomez, P.; Sousa, J.
Date: 2023
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Origin: Repositório Institucional da UNL
Protein conformational flexibility modulates kinetics and thermodynamics of dru...
Amaral, Marta; Kokh, D. B.; Bomke, J.; Wegener, A.; Buchstaller, H. P.; Eggenweiler, H. M.; Matias, P.; Sirrenberg, C.; Wade, R. C.; Frech, M.Structure-based drug design has often been restricted by the rather static picture of protein-ligand complexes presented by crystal structures, despite the widely accepted importance of protein flexibility in biomolecular recognition. Here we report a detailed experimental and computational study of the drug target, human heat shock protein 90, to explore the contribution of protein dynamics to the binding ther...
Date: 2017
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Origin: Repositório Institucional da UNL