9 documents found, page 1 of 1
Adrenal Vein Sampling in the Management of Primary Aldosteronism: The Added Val...
Manique, I; Amaral, S; Matias, A; Bouça, B; Serranito, S; Torres, J; Gutu, O; Bilhim, T; Coimbra, E; Rodrigues, I; Godinho, C; Cortez, L; Silva-Nunes, JIntroduction: Primary aldosteronism is the most common cause of secondary hypertension. Adrenal vein sampling is the gold standard for subtyping primary aldosteronism. However, this procedure is technically challenging and often has a low success rate. Our center is one of the very few performing this technique in our country with an increasing experience. Objective: The aim of this study was to evaluate the ro...
Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy agai...
Silva, G; Sales-Dias, J; Casal, D; Alves, S; Domenici, G; Barreto, C; Matos, C; Lemos, A; Matias, A; Kucheryava, K; Ferreira, A; Moita, MR; Braga, SThe Notch-signaling ligand DLL1 has emerged as an important player and promising therapeutic target in breast cancer (BC). DLL1-induced Notch activation promotes tumor cell proliferation, survival, migration, angiogenesis and BC stem cell maintenance. In BC, DLL1 overexpression is associated with poor prognosis, particularly in estrogen receptor-positive (ER+) subtypes. Directed therapy in early and advanced BC...
Twin Pregnancies, Crown-rump Length and Birthweight Discordancy: The Influence ...
Nunes, JS; Sousa, M; Montenegro, N; Matias, AObjective: The purpose of the present study was to analyze the influence of chorionicity in the biometric parameters crown-rump length (CRL), birthweight (BW), crown-rump length discordancy (CRLD) and birthweight discordancy (BWD), determine the correlation between these latter two in cases of intertwin discordancy, and to analyze the influence of chronicity in the presence of these discordancies with clinical ...
Ductus venosus agenesis and fetal malformations: what can we expect? - a system...
Pacheco, D; Brandao, O; Montenegro, N; Matias, ABackground: The ductus venosus agenesis (DVA) is a rare condition with a variable prognosis that relies partly on the presence of associated conditions. The purpose of our study was to analyze the literature regarding the postnatal outcome of fetuses with DVA associated with fetal malformations, in order to discuss the best management options for couples. Methods: We performed a systematic review of the literat...
Can early β-human chorionic gonadotropin predict birth of singletons and twins ...
Póvoa, A; Severo, M; Xavier, P; Matias, A; Blickstein, IObjective: To assess the predictive value for clinical pregnancy outcome of β-hCG level at 13 d after embryo transfer. Methods: Retrospective study of IVF clinical pregnancies diagnosed at 6 weeks. We calculated the value of β-hCG level at 13 d after embryo transfer to predict live births. Results: We analyzed 177 IVF cycles between 2009 and 2014 (50 singleton births, 50 twin births, 27 sets with a vanishing tw...
Cervical pessary for the prevention of preterm birth: is it of any use?
Falcão, V; Melo, C; Matias, A; Montenegro, NAbstract: Preterm birth (PTB) represents a heavy burden in modern obstetrics as it is a major cause of perinatal morbidity and mortality. After the introduction of transvaginal sonography (TVS) screening, secondary prevention of PTB has been re-evaluated on the basis of pre-existing cervical length (CL) and meanwhile the cervical pessary has become an object of increasing interest. This device consists of a sil...
Amniocentesis in a tertiary referral centre: still the same old story?
Monteiro, S; Matias, A; Loureiro, T; Cunha, M; Azevedo, A; Montenegro, NOverview and Aims: The main objective of this study was to describe the main clinical indications, diagnostic yield, complications and pregnancy outcomes regarding amniocentesis performed in a tertiary University Hospital, during an 8-year period. Study Design: We developed an observational, retrospective study, of all amniocenteses performed between June 2003 and June 2011. Population: All pregnant women conse...
Cortical maturation in fetuses referred for ‘isolated’ mild ventriculomegaly : ...
Miguelote, Rui; Vides, B.; Santos, R. F.; Palha, Joana Almeida; Matias, A; Sousa, NunoObjectives To compare cortical maturation between fetuses with isolated mild ventriculomegaly (IMV) and healthy fetuses, and to explore its potential prognostic value in IMV. Methods This prospective study quantified cortical maturation by ultrasound in 24 fetuses with IMV and 46 healthy fetuses. Depth and grading the developmental pattern of the parieto-occipital fissure (POF), calcarine fissure (CF) and sylvi...
Cortical maturation in fetuses referred for ‘isolated’ mild ventriculomegaly: a...
Miguelote, RF; Vides, B; Santos, RF; Palha, JA; Matias, A; Sousa, NOBJECTIVES: To compare cortical maturation between fetuses with isolated mild ventriculomegaly (IMV) and healthy fetuses, and to explore its potential prognostic value in IMV. METHODS: This prospective study quantified cortical maturation by ultrasound in 24 fetuses with IMV and 46 healthy fetuses. Depth and grading the developmental pattern of the parieto-occipital fissure (POF), calcarine fissure (CF) and syl...