Effective antimicrobial treatment has been identified as a serious and unmet medical need. Herein, we present a strategy based on deep eutectic systems (DES) to overcome current limitations, answering the need not only to effectively kill bacterial agents but also to avoid their adhesion and proliferation, which is associated with biofilm formation and have a crucial impact on bacterial virulence. To achieve su...
Abstract Purpose The aim of this study is to identify and characterize kids' menu offer in fast-food and traditional restaurants located in shopping centres in five different countries. Design/methodology/approach An observational cross-sectional study is carried out, though a study was performed in all restaurants located in shopping centres from main cities, in five countries: Brazil, Chile, Croatia, Hungary ...
Therapeutic deep eutectic systems (THEDES) have dramatically expanded their popularity in the pharmaceutical field due to their ability to increase active pharmaceutical ingredients (APIs) bioavailability. However, their biological performance has not yet been carefully scrutinized. Herein, THEDES based on the binary mixture of perillyl alcohol (POH) and ibuprofen (IBU) were prepared using different molar ratio...
Uma das recentes áreas de estudo em migrações internacionais na Europa tem sido o crescente peso demográfico de populações de línguas ditas imigrantes não-europeias. Sendo uma realidade do final da Segunda Guerra Mundial e da diversidade de fenómenos migratórios de massa desde aí emergentes -- com consequências demográficas na composição da população na Europa Ocidental -- a visibilidade da sua diversidade ling...
A major concern of coastal engineering is not only to access the damage to coastal structures by severe wave overtopping, but also the hazard imposed to users. Local hazard is often associated to the volume of overtopping water per unit of time (called overtopping discharge). Despite two decades of intensive research, it is yet not fully clear to practitioners what is the best method to compute the discharge pa...
Objectives To determine the accuracy of measuring the corpus callosum (CC) length in reconstructed mid-sagittal views obtained by 3D multiplanar manipulations or volume contrast imaging in the C-plane (VCI-C) in comparison to measurements obtained by direct mid-sagittal view. Methods Forty-six normal fetuses were examined by 2D and 3D ultrasound between 23 and 32 weeks of gestation. Direct mid-sagittal views we...
It has been described that fullerenes (C60) present interesting properties with potential application in clinical conditions related to oxidative stress. One of the most prominent features of fullerenes is the ability to quench free radicals. However, because of its poor solubility, this has been studied mostly in organic solutions, while the antioxidant activity and cytotoxicity of fullerenes and their derivat...
Vertical lowering (downwearing) of shore platform surfaces is a very important mechanism in their morphological evolution albeit much remains incompletely understood. The efficacy of mechanical and chemical weathering acting on a given substrate, together with erosional processes, influences downwearing rates. In order to determine the relationship between lithotypes and downwearing rates, data collected from a...
Vertical lowering (downwearing) of shore platform surfaces is a very important mechanism in their morphological evolution albeit much remains incompletely understood. The efficacy of mechanical and chemical weathering acting on a given substrate, together with erosional processes, influences downwearing rates. In order to determine the relationship between lithotypes and downwearing rates, data collected from a...