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High-frequency oscillatory ventilation in children: a 10-year experience

Moniz, M; Silvestre, C; Nunes, P; Abadesso, C; Matias, E; Loureiro, H; Almeida, HI

OBJECTIVES: The aim of the study was to describe the experience with high-frequency oscillatory ventilation (HFOV) in a Portuguese Pediatric Critical Care Unit, and to evaluate whether HFOV allowed improvement in oxygenation and ventilation. METHODS: This was a retrospective observational cohort study of children ventilated by HFOV between January, 2002 and December, 2011. The following parameters were recorded...


Non-invasive ventilation in acute respiratory failure in children

Abadesso, C; Nunes, P; Silvestre, C; Matias, E; Loureiro, H; Almeida, HI

BACKGROUND: There is only sparse data on the use of non-invasive ventilation (NIV) in acute respiratory failure (ARF) in infants and children. For this setting we investigated feasibility and efficacy of NIV and aimed to identify early predictors for treatment failure. PATIENTS AND METHODS: Retrospective chart review was performed for all patients treated with NIV for ARF from 2003 to 2010 on an 8-bed pediatric...


H1N1 disseminated infection in a 3-month-old boy

Moniz, M; Nunes, P; Silvestre, C; Abadesso, C; Matias, E; Loureiro, H; Almeida, H

Earlier this year a new influenza virus emerged. In children, the clinical manifestations of H1N1 infection are similar to those reported during periods of seasonal influenza. We report on a 3-month-old boy with an upper respiratory tract infection who presented enteropathy, coagulopathy and encephalitis related to H1N1. The infection was confirmed in nasopharyngeal aspirate, stools and cerebrospinal fluid by r...


Familial haemophagocytic lymphohistiocytosis: two case reports

Ferreira, M; Martins, J; Silvestre, C; Abadesso, C; Matias, E; Loureiro, H; Figueiredo, A; Dias, A; Almeida, HI

Haemophagocytic lymphohistiocytosis (HLH) is a life threatening inflammatory syndrome, which presents a highly stimulated but ineffective immune response with severe hypercytokinaemia. HLH, primary or secondary, is characterised by prolonged fever and hepatosplenomegaly associated with pancytopenia, hypertriglyceridaemia and hypofibrinogenaemia. However, the hallmark of HLH is impaired or absent function of nat...


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