2 documents found, page 1 of 1
VASCULAR SURGERY AND MYOCARDIAL INJURY AFTER NONCARDIAC SURGERY (MINS): LITERAT...
Nóbrega, Leandro; Pereira-Macedo, Juliana; Machado, Neuza; Pereira-Neves, António; Ferreira, Vitor; Oliveira-Pinto, José; Dias-Neto, MarinaINTRODUCTION: After noncardiac surgery, cardiac complications are common. Recently there is one that has gained notoriety as risk factor for cardiovascular morbidity and mortality, myocardial injury after noncardiac surgery (MINS). It has an estimated incidence of 8% and is associated with an increased risk of major adverse cardiovascular events (MACE). Thus, the aim of this paper is to review the available lit...
Discovery of a new small-molecule inhibitor of p53–MDM2 interaction using a yea...
Leão, Mariana; Pereira, Clara; Bisio, Alessandra; Ciribilli, Yari; Paiva, Ana M.; Machado, Neuza; Palmeira, Andreia; Fernandes, Miguel X.; Sousa, EmíliaThe virtual screening of a library of xanthone derivatives led us to the identification of potential novel MDM2 ligands. The activity of these compounds as inhibitors of p53–MDM2 interaction was investigated using a yeast phenotypic assay, herein developed for the initial screening. Using this approach, in association with a yeast p53 transactivation assay, the pyranoxanthone (3,4-dihydro-12- hydroxy-2,2-dimeth...