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Surface activation of medical grade polyurethane for the covalent immobilizatio...

Matinha-Cardoso, J; Mota, R; Gomes, LC; Gomes, M; Mergulhao, F; Tamagnini, P; Martins, MCL; Costa, F

Hospital-acquired infections are still a major concern worldwide, being frequently related to bacterial biofilm formation on medical devices, and thus difficult to eradicate with conventional antimicrobial treatments. Therefore, infection-preventive solutions based on natural polymers are being investigated. Recently, a marine cyanobacterium-derived polymeric coating (CyanoCoating) has demonstrated great anti-a...


The role of outer membrane protein(S) harboring slh/oprb-domains in extracellul...

Cardoso, D; Lima, S; Matinha-Cardoso, J; Tamagnini, P; Oliveira, P

Cyanobacteria are a group of photosynthetic prokaryotes that contribute to primary production on a global scale. These microorganisms release vesicles to the extracellular environment, spherical nanosized structures, derived essentially from the outer membrane. Even though earlier works in model Gram-negative bacteria have hypothesized that outer membrane stability is crucial in vesicle formation, the mechanism...


Extracellular vesicles: An overlooked secretion system in cyanobacteria

Lima, S; Matinha-Cardoso, J; Tamagnini, P; Oliveira, P

In bacteria, the active transport of material from the interior to the exterior of the cell, or secretion, represents a very important mechanism of adaptation to the surrounding environment. The secretion of various types of biomolecules is mediated by a series of multiprotein complexes that cross the bacterial membrane(s), each complex dedicated to the secretion of specific substrates. In addition, biological ...


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