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Cellulose-based colorimetric test strips for SARS-CoV-2 antibody detection

Sousa, Mariana; Pereira, Ana Cláudia; Correia, Bárbara; Carmo, Anália do; Matos, Ana Miguel; Cruz, Maria Teresa; Moreira, Felismina

The COVID-19 pandemic highlighted the need for rapid, cost-effective tools to monitor transmission and immune response. We developed two novel paper-based colorimetric biosensors using glutaraldehyde as a protein dyeits first use in this context. Glutaraldehyde reacts with amino groups to generate a brown color, enabling detection of SARS-CoV-2 antibodies. Wathman filter paper was functionalized with (3-aminopr...


Development of colorimetric cellulose-based test-strip for the rapid detection ...

Correia, Bárbara P.; Sousa, Mariana P.; Sousa, Cristina E. A.; Mateus, Daniela; Sebastião, Ana Isabel; Cruz, Maria Teresa; Matos, Ana Miguel

Given the pandemic situation, there is an urgent need for an accurate test to monitor antibodies anti-SARS-CoV-2, providing crucial epidemiological and clinical information to monitor the evolution of coronavirus disease in 2019 (COVID-19) and to stratify the immunized and asymptomatic population. Therefore, this paper describes a new cellulosebased test strip for rapid and cost-efective quantitative detection ...


Development of colorimetric cellulose-based test-strip for the rapid detection ...

Correia, Bárbara; Sousa, Mariana; Sousa, Cristina; Mateus, Daniela; Sebastião, Ana Isabel; Cruz, Maria Teresa; Matos, Ana Miguel

Given the pandemic situation, there is an urgent need for an accurate test to monitor antibodies anti-SARS-CoV-2, providing crucial epidemiological and clinical information to monitor the evolution of coronavirus disease in 2019 (COVID-19) and to stratify the immunized and asymptomatic population. Therefore, this paper describes a new cellulose-based test strip for rapid and cost-effective quantitative detectio...


Paper-based biosensors for COVID-19: a review of innovative tools for controlli...

Pinheiro, Tomás; Cardoso, A. Rita; Sousa, Cristina E. A.; Marques, Ana C.; Tavares, Ana P. M.; Matos, Ana Miguel; Cruz, Maria Teresa

The appearance and quick spread of the new severe acute respiratory syndrome coronavirus disease, COVID-19, brought major societal challenges. Importantly, suitable medical diagnosis procedures and smooth clinical management of the disease are an emergent need, which must be anchored on novel diagnostic methods and devices. Novel molecular diagnostic tools relying on nucleic acid amplification testing have emer...


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