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Nanoencapsulation as a novel delivery approach for therapeutic applications of ...

Araújo, Nuna; Viegas, Carla; Pontes, Jorge F.; Marreiros, Catarina; Raimundo, Pedro; Macedo, Anjos L.; Matos, António Alves de; Grenha, Ana


Gut status in Parkinson’s disease: the GutSPark protocol

Grunho, Miguel; Godinho, Catarina; Matos, António Alves de; Barroso, Helena; Carregosa, Ricardo; Marx, Frederico; Tomé, Morgane; Domingos, Josefa

The neuropathological hallmark of Parkinson’s disease (PD) is the accumulation of alpha–synuclein (AS) aggregates. The identification of AS aggregates in gut biopsy specimens from people with PD may provide an opportunity to identify PD at a very early stage, prior to symptom onset. Changes in gut microbiota and inflammatory conditions (such as periodontitis) may be linked with PD onset/evolution. This project ...


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