17 documents found, page 1 of 2
The Impact of Lifestyle on Prostate Cancer: A Road to the Discovery of New Biom...
Leitão, Catarina; Matos, Bárbara; Roque, Fátima; Herdeiro, Maria Teresa; Fardilha, MargaridaProstate cancer (PCa) is one of the most common cancers among men, and its incidence has been rising through the years. Several risk factors have been associated with this disease and unhealthy lifestyles and inflammation were appointed as major contributors for PCa development, progression, and severity. Despite the advantages associated with the currently used diagnostic tools [prostate-specific antigen(PSA) ...
The World Café method and spaces dedicated to active teaching & learning: A dyn...
Pinto-Pinho, Patrícia; Ferreira, Ana; Matos, Bárbara; Santiago, Joana; Henriques, Magda Carvalho; Corda, Pedro Oliveira; Lima, Tânia; Rodrigues, MárioA pilot experiment was developed in a Biomedical Sciences curricular unit to test how using a different knowledge-sharing method (World Café) in a Space for Active Learning and Teaching would affect students’ engagement. Each working group was asked to prepare a poster summarising a different topic about the physiology of the oocyte. On the activity day, rotating discussion sessions moderated by tutors took pla...
Stem Cell Bioengineering with Bioportides: Inhibition of Planarian Head Regener...
Jones, Sarah; Matos, Bárbara; Dennison, Sarah; Fardilha, Margarida; Howl, JohnDjeya1 (RKLAFRYRRIKELYNSYR) is a very effective cell penetrating peptide (CPP) that mimics the α5 helix of the highly conserved Eya domain (ED) of eyes absent (Eya) proteins. The objective of this study was to bioengineer analogues of Djeya1 that, following effective translocation into planarian tissues, would reduce the ability of neoblasts (totipotent stem cells) and their progeny to regenerate the anterior p...
Engaging large classes of higher education students: a combination of spaced le...
Carlos, Vânia; Rodrigues, Mário; Matos, Bárbara; Gonçalves, Lurdes; Ribeiro, Fernando; Fardilha, MargaridaWe are in an era where keeping students focused and interested can be challenging. Furthermore, it is relevant, in avoiding students dropping out and increasing students’ achievements, to research how student engagement can be nurtured and how this aspect is influenced by teacher attitude and the teaching and learning (T and L) approaches. With the purpose of engaging a large biochemistry class of first-year st...
A Review of Energy and Sustainability KPI-Based Monitoring and Control Methodol...
Matos, Bárbara; Salles, Rodrigo; Mendes, Jérôme; Gouveia, Joana R.; Baptista, António J.; Moura, PedroHumanity faces serious problems related to water supply, which will be aggravated by population growth. The water used in human activities must be treated to make it available again without posing risks to human health and the environment. In this context,Wastewater Treatment Plants (WWTPs) have gained importance. The treatment process in WWTPs is complex, consisting of several stages, which consume considerabl...
The Impact of Lifestyle on Prostate Cancer: A Road to the Discovery of New Biom...
Leitão, Catarina; Matos, Bárbara; Roque, Fátima; Herdeiro, Maria Teresa; Fardilha, MargaridaProstate cancer (PCa) is one of the most common cancers among men, and its incidence has been rising through the years. Several risk factors have been associated with this disease and unhealthy lifestyles and inflammation were appointed as major contributors for PCa development, progression, and severity. Despite the advantages associated with the currently used diagnostic tools [prostate-specific antigen(PSA) ...
Tracking Prostate Carcinogenesis over Time through Urine Proteome Profiling in ...
Moreira-Pais, Alexandra; Nogueira-Ferreira, Rita; Reis, Stephanie; Aveiro, Susana; Barros, António; Melo, Tânia; Matos, Bárbara; Duarte, José AlbertoProstate cancer (PCa) is one of the most lethal diseases in men, which justifies the search for new diagnostic tools. The aim of the present study was to gain new insights into the progression of prostate carcinogenesis by analyzing the urine proteome. To this end, urine from healthy animals and animals with prostate adenocarcinoma was analyzed at two time points: 27 and 54 weeks. After 54 weeks, the incidence ...
PP1 catalytic isoforms are differentially expressed and regulated in human pros...
Felgueiras, Juliana; Lobo, João; Camilo, Vânia; Carneiro, Isa; Matos, Bárbara; Henrique, Rui; Jerónimo, Carmen; Fardilha, MargaridaThe Ser/Thr-protein phosphatase PP1 (PP1) is a positive regulator of the androgen receptor (AR), which suggests major roles for PP1 in prostate carcinogenesis. However, studies dedicated to the characterization of PP1 in PCa are currently scarce. Here we analyzed the expression and localization of the PP1 catalytic (PP1c) isoforms in formalin-fixed, paraffin-embedded prostate tissue samples, as well as in PCa c...
Effects of Age and Lifelong Moderate-Intensity Exercise Training on Rats' Testi...
Silva, Joana V.; Santiago, Joana; Matos, Bárbara; Henriques, Magda C.; Patrício, Daniela; Martins, Ana D.; Duarte, José A.; Ferreira, RitaAging is associated with testicular morphological and functional alterations, but the underlying molecular mechanisms and the impact of physical exercise are poorly understood. In this study, we examined the effects of age and lifelong moderate-intensity exercise on rat testis. Mature adults (35 weeks) and middle-aged (61 weeks) Wistar Unilever male rats were maintained as sedentary or subjected to a lifelong m...
Tracking prostate carcinogenesis over time through urine proteome profiling in ...
Moreira-Pais, Alexandra; Nogueira-Ferreira, Rita; Reis, Stephanie; Aveiro, Susana; Barros, António; Melo, Tânia; Matos, Bárbara; Duarte, José AlbertoProstate cancer (PCa) is one of the most lethal diseases in men, which justifies the search for new diagnostic tools. The aim of the present study was to gain new insights into the progression of prostate carcinogenesis by analyzing the urine proteome. To this end, urine from healthy animals and animals with prostate adenocarcinoma was analyzed at two time points: 27 and 54 weeks. After 54 weeks, the incidence ...