8 documents found, page 1 of 1

Elastic and Ultradeformable Liposomes for Transdermal Delivery of Active Pharma...

Administration of active pharmaceutical ingredients (APIs) through the skin, by means of topical drug delivery systems, is an advanced therapeutic approach. As the skin is the largest organ of the human body, primarily acting as a natural protective barrier against permeation of xenobiotics, specific strategies to overcome this barrier are needed. Liposomes are nanometric-sized delivery systems composed of phos...

Nanoencapsulation of bovine lactoferrin for food and biopharmaceutical applicat...

Lactoferrin has for long captured the interest of many researchers as a natural compound with a wide variety of uses. Lactoferrin is a monomeric, iron-binding 80 kDa glycoprotein, and appears to be the subfraction of whey with the best documented antiviral, antimicrobial, anticancer and immune modulating/enhancing effects. It belongs to the family of transferrin proteins, and serves to control iron levels in bo...

Correlation between octanol/water and liposome/water distribution coefficients ...

Absorption and consequent therapeutic action are key issues in the development of new drugs by the pharmaceutical industry. In this sense, different models can be used to simulate biological membranes to predict the absorption of a drug. This work compared the octanol/water and the liposome/water models. The parameters used to relate the two models were the distribution coefficients between liposomes and water ...

Nanoencapsulation of bovine lactoferrin for food and biopharmaceutical applicat...

Lactoferrin has for long captured the interest of many researchers as a natural compound with a wide variety of uses. Lactoferrin is a monomeric, iron-binding 80 kDa glycoprotein, and appears to be the subfraction of whey with the best documented antiviral, antimicrobial, anticancer and immune modulating/enhancing effects. It belongs to the family of transferrin proteins, and serves to control iron levels in bo...

Nanocarrier possibilities for functional targeting of bioactive peptides and pr...

This review attempts to provide an updated compilation of studies reported in the literature pertaining to production of nanocarriers encasing peptides and/or proteins, in a way that helps the reader direct a bibliographic search and develop an integrated perspective of the subject. Highlights are given to bioactive proteins and peptides, with a special focus on those from dairy sources (including physicochemic...

Lipossomas: vectores atractivos e versáteis para o direccionamento de (bio)fárm...

Os lipossomas são microsistemas constituídos por uma ou mais bicamadas lipídicas dispostas esfericamente, separadas por fases aquosas, cujo cerne é um compartimento aquoso. Tais estruturas esféricas fechadas, cujo diâmetro varia tipicamente entre os 50 nm e os 5 mm, formam-se espontaneamente quando alguns lípidos são colocados em solução aquosa. Logo após a sua descoberta, na década de sessenta, surgiu a ideia ...

Encapsulação de dois fármacos anticancerígenos (5-fluorouracilo e metotrexato) ...

Este trabalho descreve os resultados preliminares da eficiência de encapsulação de dois fármacos anticancerígenos em liposomas com o intuito de desenvolver uma formulação de cedência modificada. Apresentam-se os resultados da determinação da eficiência de encapsulação de dois anticancerígenos (5-fluorouracilo e metotrexato) em lipossomas unilamelares (LU V) de fosfatidilcolina da gema do ovo (EPC). Estes fármac...

Nanoencapsulation of bovine lactoferrin for oral hygiene applications