242 documents found, page 1 of 25

A prototype to enhance academic attendance using BLE beacons

This project addresses the prototyping and application of an attendance control solution in an academic context, using Beacons. The introduction highlights the importance of effectively managing student attendance to ensure active participation in educational activities and provide insights into student engagement. BLE Beacons technology is compared to other RF signaling technologies, highlighting its advantage...

Consumption performance, of a multi agent system used to achieve comfort prefer...

First Online: 26 September 2023; In this work, a multi-agent system was developed to manage comfort preferences, in an autonomous and completely automatic and non-invasive way for the user. This system was based on the use of an architecture supported by low cost hardware, namely Raspberrys, to support the different actuators present in the different spaces. To carry out its validation, a methodology was create...

Efeitos da aflatoxina B1 na integridade e morfologia de células intestinais

YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cel...

Recent developments in CFTR modulator drugs have had a significant transformational effect on the treatment of individuals with Cystic Fibrosis (CF) who carry the most frequent F508del- CFTR mutation in at least one allele. However, the clinical effects of these revolutionary drugs remain limited by their inability to fully restore the plasma membrane (PM) stability of the rescued mutant channels. Here, we shed...

DIS3L2: Unveiling a New Player in Tumorigenesis, with a Key Role in Colorectal ...

DIS3L2 is a 3’-5’ exoribonuclease that recognizes and degrades uridylated transcripts in an exosome-independent manner and participates in several RNA degradation pathways, such as the nonsense-mediated mRNA decay, or the surveillance of aberrant structured non-coding RNAs. Although some studies have linked DIS3L2 to tumorigenesis and cancer-related processes, its exact role in the development and progression o...

IL-6 induces the overexpression of genes involved in the regulation of apoptosi...

Introduction: An inflammatory microenvironment was identified as a critical tumor-promoting condition for cells harboring tumor-initiating mutations. Cancer cells respond to pro-inflammatory signals with changes in their transcriptome, namely upregulating the expression of pro-tumorigenic transcript variants. A paradigmatic example is the variant RAC1B. We found increased RAC1B levels in samples from inflammato...

SRC/RAC1 Pathway and other NIS Plasma Membrane Interactors in NIS Regulation

The Sodium/Iodide Symporter (NIS) is responsible for the uptake of iodide into thyroid follicular cells, which is required for thyroid hormone production. NIS is present in most differentiated thyroid carcinoma (DTC) cells, allowing radioactive iodine (RAI) to be used to eliminate any residual disease after thyroidectomy. However, in advanced DTC, a significant proportion of metastatic lesions stop taking up io...

DIS3L2 knockdown impairs key oncogenic properties of colorectal cancer cells vi...

DIS3L2 degrades different types of RNAs in an exosome-independent manner including mRNAs and several types of non-coding RNAs. DIS3L2-mediated degradation is preceded by the addition of nontemplated uridines at the 3’end of its targets by the terminal uridylyl transferases 4 and 7. Most of the literature that concerns DIS3L2 characterizes its involvement in several RNA degradation pathways, however, there is so...

Aprendizagem baseada em soluções efetivas

Os autores apresentam a Aprendizagem Baseada em Soluções Efetivas que deriva da Aprendizagem Baseada em Projeto, mas aplicada a problemas reais com objetivo de contruir soluções efetivas. A enfase é colocada na efetividade no pressuposto que incentiva a um maior envolvimento e comprometimento por parte dos alunos, assegurando um contexto que se pretende mais aliciante e próximo do que será a realidade profissio...

A solution to prevent and minimize the consequences of accidents with farm trac...

Farm tractors have become a key part of daily routine agriculture, converting complex and time-consuming tasks into tasks that are easier to perform and less dependent on human labor, contributing directly to increasing the economic value generated by this activity sector, either by increasing the productivity or by making certain agricultural crops viable, which otherwise would not be sustainable. However, des...