248 documents found, page 1 of 25
Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolis...
Martins, Filipa; Arada, Renata; Barros, Hélio; Matos, Paulo; Ramalho, José; Ceña, Valentín; Bonifácio, Vasco D.B.; Gonçalves, Luís G.; Serpa, JacintaGlioblastoma (GBM) is a highly lethal disease with limited treatment options due to its infiltrative nature and the lack of efficient therapy able to cross the protective blood-brain barrier (BBB). GBMs are metabolically characterized by increased glycolysis and glutamine dependence. This study explores a novel metabolism-based therapeutic approach using a polyurea generation 4 dendrimer (PURE) surface function...
CCL2 expression predicts clinical outcomes and regulates E-cadherin and angioge...
Silva, Ana Luísa; Barry, Sayka; Lopes-Pinto, Mariana; Joaquim, Rita; Miranda, Catarina; Reis, Fábio; Miranda, Micaella; Matos, Paulo; Suleyman, OnizThe crosstalk between tumour cells and microenvironment components in pituitary neuroendocrine tumours (PitNETs), including chemokines, may impact tumour behaviour and clinical outcomes. CCL2 was previously identified as a key chemokine in PitNETs, but its role remains unknown. We aimed to study the role of CCL2 in defining the phenotype and clinical outcomes of PitNETs and in regulating macrophage chemotaxis, ...
Alternative Splicing at the Crossroad of Inflammatory Bowel Diseases and Coliti...
Matos, Paulo; Jordan, PeterSimple Summary: Patients with ulcerative colitis (UC) face a higher risk of developing colorectal cancer (CRC) due to chronic inflammation, a known promoter of tumour growth. Here, we review the molecular differences between colitis-associated cancer (CAC) and sporadic CRC, with a focus on “alternative splicing”, a mechanism by which the same gene can produce various protein forms. We explore how inflammation t...
Assessing the impact of TiO2 nanomaterials on intestinal cells: New evidence fo...
Rolo, Dora; Pereira, Joana F.S.; Gonçalves, Lídia; Bettencourt, Ana; Jordan, Peter; Silva, Maria João; Matos, Paulo; Louro, HenriquetaUnderstanding the potential impact of nanomaterials (NMs) on human health requires further investigation into the organ-specific nano-bio interplay at the cellular and molecular levels. We showed increased chromosomal damage in intestinal cells exposed to some of in vitro digested Titanium dioxide (TiO2) NMs. The present study aimed to explore possible mechanisms linked to the uptake, epithelial barrier integri...
Análise de coortes genómicas públicas de larga escala revelam BCL6 como marcado...
Barros, Patrícia; Jordan, Peter; Matos, PauloO cancro da mama (CM) é a neoplasia maligna mais comum entre mulheres a nível mundial, constituindo uma das principais causas de mortalidade oncológica. Representa uma doença heterogénea, agrupada em subtipos moleculares com implicações prognósticas e terapêuticas distintas. O subtipo Luminal A é o mais prevalente e caracteriza-se por elevada expressão de recetores hormonais (estrogénio e progesterona), baixa t...
A prototype to enhance academic attendance using BLE beacons
Simas, Sily; Oliveira, Pedro Filipe; Matos, PauloThis project addresses the prototyping and application of an attendance control solution in an academic context, using Beacons. The introduction highlights the importance of effectively managing student attendance to ensure active participation in educational activities and provide insights into student engagement. BLE Beacons technology is compared to other RF signaling technologies, highlighting its advantage...
SRC/RAC1 Pathway and other NIS Plasma Membrane Interactors in NIS Regulation
Silva, Ana Luísa; Matos, PauloThe Sodium/Iodide Symporter (NIS) is responsible for the uptake of iodide into thyroid follicular cells, which is required for thyroid hormone production. NIS is present in most differentiated thyroid carcinoma (DTC) cells, allowing radioactive iodine (RAI) to be used to eliminate any residual disease after thyroidectomy. However, in advanced DTC, a significant proportion of metastatic lesions stop taking up io...
DIS3L2 knockdown impairs key oncogenic properties of colorectal cancer cells vi...
García-Moreno, Juan F.; Lacerda, Rafaela; da Costa, Paulo J.; Pereira, Marcelo; Gama-Carvalho, Margarida; Matos, Paulo; Romão, LuísaDIS3L2 degrades different types of RNAs in an exosome-independent manner including mRNAs and several types of non-coding RNAs. DIS3L2-mediated degradation is preceded by the addition of nontemplated uridines at the 3’end of its targets by the terminal uridylyl transferases 4 and 7. Most of the literature that concerns DIS3L2 characterizes its involvement in several RNA degradation pathways, however, there is so...
Aprendizagem baseada em soluções efetivas
Matos, Paulo; Alves, Rui; Gonçalves, JoséOs autores apresentam a Aprendizagem Baseada em Soluções Efetivas que deriva da Aprendizagem Baseada em Projeto, mas aplicada a problemas reais com objetivo de contruir soluções efetivas. A enfase é colocada na efetividade no pressuposto que incentiva a um maior envolvimento e comprometimento por parte dos alunos, assegurando um contexto que se pretende mais aliciante e próximo do que será a realidade profissio...
A solution to prevent and minimize the consequences of accidents with farm trac...
Alves, Rui; Matos, PauloFarm tractors have become a key part of daily routine agriculture, converting complex and time-consuming tasks into tasks that are easier to perform and less dependent on human labor, contributing directly to increasing the economic value generated by this activity sector, either by increasing the productivity or by making certain agricultural crops viable, which otherwise would not be sustainable. However, des...