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Complete blood count parameters as biomarkers of retinopathy of prematurity: a ...
Fevereiro-Martins, M; Santos, AC; Marques-Neves, C; Guimarães, H; Bicho, M; Afonso, C; Ferreira, J; Espírito Santo, R; Teixeira, F; Rosa, RPurpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory d...
Pregnancy with anti-PP1Pk antibody managed with prednisolone and low-molecular-...
Nascimento, S; Rodrigues, M; Henriques, M; Duarte, FP; Barra, A; Matos, TThe anti-PP1Pk is a rare antibody associated with recurrent miscarriages, mainly in the first half of pregnancy. There seems to be a direct correlation between the antibody titer and risk of miscarriage. As this is a rare entity, few case reports have been published. The most frequently proposed therapeutic approaches are doublefiltration plasmapheresis and plasma exchange therapy. The rationale behind them is ...
The Dark Side of the Light: Mechanisms of Photocarcinogenesis
Valejo Coelho, M; Matos, T; Apetato, MUltraviolet radiation (UVR) can have a beneficial biologic impact on skin, but it is also the most significant environmental risk factor for skin cancer development. Photocarcinogenesis comprises a complex interplay between the carcinogenic UVR, skin, and the immune system. UVB is absorbed by the superficial skin layers and is mainly responsible for direct DNA damage, which, if unrepaired, can lead to mutations...
Spectrum and Frequency of GJB2 Mutations in a Cohort of 264 Portuguese Nonsyndr...
Matos, T; Simões-Teixeira, H; Caria, H; Gonçalves, AC; Chora, J; Correia, MC; Moura, C; Rosa, H; Monteiro, L; O'Neill, A; Dias, O; Andrea, M; Fialho, GOBJECTIVE: To assess the spectrum and prevalence of mutations in the GJB2 gene in Portuguese nonsyndromic sensorineural hearing loss (NSSHL) patients. DESIGN: Sequencing of the coding region, basal promoter, exon 1, and donor splice site of the GJB2 gene; screening for the presence of the two common GJB6 deletions. STUDY SAMPLE: A cohort of 264 Portuguese NSSHL patients. RESULTS: At least one out of 21 differen...
Complexo íntima-média e patologia hipertensiva associada à gravidez: um estudo ...
Veríssimo, C; Campillo, J; Matos, T; Costa, A; Rocha, IObjectivos: Avaliar o complexo íntima-média(ClM)em grávidas hipertensas e determinar se um CIM aumentado está relacionado com o desenvolvimento da pré-eclâmpsia. Métodos:Elaborou-se um estudo prospectivo, descritivo e controlado na Unidade de Medicina Materno-Fetal de um hospital de nível II com apoio perintal direnciado. Durante seis meses, 48 grávidas aleatoriamente seleccionadas foram distribuidas por três g...
Trombose do sistema venoso porta após o parto numa doente com síndrome de antic...
Veríssimo, C; Matos, T; Dutschmann, L; Rocha, IIntrodução: A síndrome de anticorpos antifosfolípidos (SAAF) é uma trombofilia autoimune de etiologia mal definida e que condiciona tromboses vasculares e complicações gestacionais. Caso clínico: Uma mulher de 27 anos de idade com diagnóstico de SAAF previamente estabelecido recorreu ao Serviço de Urgência por dor no hipocôndrio direito cinco dias após parto eutócico de termo. As análises demonstraram elevação ...
Pancreatite aguda na gravidez: a propósito de um caso clínico
Veríssimo, C; Matos, T; Jerónimo, MIntrodução: A pancreatite aguda apresenta, habitualmente, uma evolução clínica favorável e afecta 1:3333 grávidas. As principais etiologias são a coledocolitíase, hipertrigliceridémia e alcoolismo. Caso clínico: Uma multípara de 32 anos, 33 semanas de gestação e consumo crónico de 40g de álcool/dia recorreu ao Serviço de Urgência por dor epigástrica com irradiação em cinturão. O CTG e a ecografia obstétrica dem...
Esforço multidisciplinar para a evicção de um surto de parotidite epidémica num...
Veríssimo, C; Matos, T; Matos, F; Rocha, I; Nogueira, FMumps is a disease caused by paramyxovirus, whose notification to health authorities is mandatory. Vaccination in Portugal was started in 1987. There have been several outbreaks worldwide, even in populations with high vaccination rates, but none were reported in maternity hospitals. We report the case of a 36 year-old primigravida, admitted in the 37th week of pregnancy, because of fever, painful uterine contr...
Diferença tensional entre os membros superiores: um estudo em mulheres grávidas
Veríssimo, C; Matos, T; Rocha, I; Nogueira, FAim: To ascertain the prevalence of inter-arm blood pressure difference in excess of 10 mmHg in pregnant women. Population: A total of 114 pregnant women selected at random from those admitted to our Maternal and Fetal Medicine Unit. Design: Prospective, descriptive study. Methods: Blood pressure was measured on both arms twice (same operator, method and equipment). Other variants analysed were maternal age, ad...