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An anti-inflammatory and low fermentable oligo, di, and monosaccharides and pol...

Silva, Ana Rita; Bernardo, Alexandra; Mesquita, Maria Fernanda de; Vaz-Patto, José; Moreira, Pedro; Silva, Maria Leonor; Patrícia, Padrão

Background: Fibromyalgia (FM) has been associated with dysbiosis and low-grade inflammation. Studies have reported that diet influences clinical features in FM. Objective: To evaluate the effect of an anti-inflammatory and low fermentable oligo, di, and monosaccharides and polyols (FODMAP) diet on clinical outcomes of patients with FM. Methods: This two arms Randomized Controlled Trial (NCT04007705) included 46...


Corneal sub-basal nerve plexus assessment and its association with phenotypic f...

Barcelos, Filipe; Hipólito-Fernandes, Diogo; Barcelos, Filipe; Martins, Catarina; Ângelo-Dias, Miguel; Cardigos, Joana; Martins, Catarina

Purpose: To assess and compare corneal sub-basal nerve plexus morphology with circulating lymphocyte subsets, immunologic status and disease activity in Sjögren syndrome (SjS) patients. Methods: Fifty-five SjS patients, 63 Sicca patients (not fulfilling SjS criteria), 18 rheumatoid arthritis (RA) patients and 20 healthy controls (HC) were included. Systemic disease activity in SjS was assessed with the ESSDAI s...


New Perspectives of Ocular Surface Evaluation in Primary Sjögren’s Syndrome

Cardigos, Joana; Barcelos, Filipe; Carvalho, Helena; Luis, Maria Elisa; Crisostomo, Sara; Vaz-Patto, José; Alves, Nuno

Introduction: The diagnosis of Primary Sjögren's Syndrome (pSS) is sometimes challenging, taking into account the clinical heterogeneity and the variability of diagnostic criteria fulfillment. This study aims to evaluate the tear meniscus (TM) and corneal sub-basal nerve plexus (SBNP) in a population with pSS. Material and Methods: Cross-sectional study of 50 patients with pSS and 20 healthy controls. Conventio...


Tear Meniscus and Corneal Sub-basal Nerve Plexus Assessment in Primary Sjögren ...

Cardigos, Joana; Barcelos, Filipe; Carvalho, Helena; Hipólito, Diogo; Crisóstomo, Sara; Vaz-Patto, José; Alves, Nuno

Purpose: To evaluate lower tear meniscus and corneal sub-basal nerve plexus in primary Sjögren's syndrome (pSS) and Sicca syndrome patients. Methods: Cross-sectional study of 116 patients with Sicca syndrome associated with pSS and not associated with Sjögren's syndrome (non-SS Sicca) and 20 normal control subjects. Tear meniscus height and area were measured using anterior segment optical coherence tomography;...


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