3 documents found, page 1 of 1
Design, Synthesis and Anticancer Biological Evaluation of Novel 1,4-Diaryl-1,2,...
Aleixo,Mariana A. A.; Garcia,Taís M.; Carvalho,Diego B.; Viana,Luiz H.; Amaral,Marcos S.; Kassab,Najla M.; Cunha,Marilin C.; Pereira,Indiara C.We report herein the design and synthesis via click chemistry of twelve novel triazole retinoid analogues of tamibarotene (AM80) and the evaluation of their anticancer activities against six cancer cell lines: HL60, K562, 786, HT29, MCF7 and PC3. Among the synthesized compounds, two were more potent than tamibarotene against solid tumor cells, and one of them had similar potency to tamibarotene against HL60 cel...
Synthesis and Antitrypanosomastid Activity of 1,4-Diaryl-1,2,3-triazole Analogu...
Cassamale,Tatiana B.; Costa,Eduarda C.; Carvalho,Diego B.; Cassemiro,Nadla S.; Tomazela,Carolina C.; Marques,Maria C. S.; Ojeda,MariáhSixteen 1,4-diaryl-1,2,3-triazole compounds derived from the natural products veraguensin, grandisin and machilin G were synthesized, with yields of 78-92%. Biological activity tests against Leishmania amazonensis promastigotes showed that three of these compounds were the most active, with maximum inhibitory concentration (IC50) values of 1.1, 3.71 and 7.23 µM. One compound was highly active against Leishmania...
Chemical Composition and Cytotoxic Activity of the Root Essential Oil from Jatr...
Silva,Celia E. L. da; Minguzzi,Sandro; Silva,Rogério C. L. da; Matos,Maria F. C.; Tofoli,Danilo; Carvalho,João E. de; Ruiz,Ana L. T. G.The essential oil of roots of Jatropha ribifolia, obtained by hydrodistillation, was characterized in terms of its chemical composition by chromatographic method with flame ionization detection (GC-FID) and gas chromatography coupled to electron ionization mass spectrometry (GC-MS). The analyses and identification pointed by mass fragmentation pattern and retention index revealed the presence of 49 compounds, r...