5 documents found, page 1 of 1
Recent Developments in Layer-by-Layer Assembly for Drug Delivery and Tissue Eng...
Borges, João; Zeng, Jinfeng; Liu, Xi Qiu; Chang, Hao; Monge, Claire; Garot, Charlotte; Ren, Ke-Feng; Machillot, Paul; Vrana, Nihal E; Lavalle, PhilippeSurfaces with biological functionalities are of great interest for biomaterials, tissue engineering, biophysics, and for controlling biological processes. The layer-by-layer (LbL) assembly is a highly versatile methodology introduced 30 years ago, which consists of assembling complementary polyelectrolytes or biomolecules in a stepwise manner to form thin self-assembled films. In view of its simplicity, compati...
Geometrically controlled liquefied capsules for modular tissue engineering stra...
Nadine, Sara; Patrício, Sónia G.; Barrias, Cristina C.; Choi, Insung S.; Matsusaki, Michiya; Correia, Clara R.; Mano, João F.A plethora of bioinspired cell-laden hydrogels are being explored as building blocks that once assembled are able to create complex and highly hierarchical structures recapitulating the heterogeneity of living tissues. Yet, the resulting 3D bioengineered systems still present key limitations, mainly related with limited diffusion of essential molecules for cell survival, which dictates the failure of most strat...
Liquefied microcapsules as dual-Mmcrocarriers for 3D+3D bottom-up tissue engine...
Correia, Clara R.; Bjorge, Isabel M.; Zeng, Jinfeng; Matsusaki, Michiya; Mano, João F.Cell encapsulation systems must ensure the diffusion of molecules to avoid the formation of necrotic cores. The architectural design of hydrogels, the gold standard tissue engineering strategy, is thus limited to a microsize range. To overcome such a limitation, liquefied microcapsules encapsulating cells and microparticles are proposed. Microcapsules with controlled sizes with average diameters of 608.5 ± 122....
Bioinspired multilayer membranes as potential adhesive patches for skin wound h...
Sousa, Maria Peixoto; Neto, Ana; Correia, Tiago R.; Miguel, Sónia P.; Matsusaki, Michiya; Correia, I.J.; Mano, João F.Bioinspired and adhesive multilayer membranes are produced using the layer-by-layer (LbL) assembly of chitosan (CHT), alginate (ALG) and hyaluronic acid modified with dopamine (HA-DN). Freestanding multilayer membranes without DN are also produced as a control. The success of the synthesis of HA-DN was confirmed using UV-visible spectroscopy. Scanning electron microscopy images indicate that the surface of the ...
Bioinspired multilayer membranes as potential adhesive patches for skin wound h...
Sousa, Maria P.; Neto, Ana I.; Correia, Tiago R.; Miguel, Sónia P.; Matsusaki, Michiya; Correia, Ilídio J.; Mano, João F.Bioinspired and adhesive multilayer membranes are produced using the layer-by-layer (LbL) assembly of chitosan (CHT), alginate (ALG) and hyaluronic acid modified with dopamine (HA-DN). Freestanding multilayer membranes without DN are also produced as a control. The success of the synthesis of HA-DN was confirmed using UV-visible spectroscopy. Scanning electron microscopy images indicate that the surface of the ...