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Influence of ionic liquid on polar organic compounds solubility in dense CO2 phase
Zakrzewska, Małgorzata Ewa; Borovkov, Yegor; Paninho, Ana Brandão; Petrovski, Zeljko; Najdanovic-Visak, Vesna; Nunes, Ana Vital MorgadoThis work was supported by Fundação para a Ciência e Tecnologia FCT/MCTES projects MIT-EXPL/CS/0052/2021 of the Associate Laboratory for Green Chemistry – LAQV , Publisher Copyright: © 2023 The Authors; Accurate measurement and prediction of the phase behaviour of mixtures involved in a chemical process are crucial for its optimisation. Given the importance of CO2 conversion technologies and considering possibl...
Bioactivity of Ionic Liquids Based on Valproate in SH-SY5Y Human Neuroblastoma ...
Dias, Ana Rita; Ferraz, Ricardo; Costa-Rodrigues, João; Santos, Andreia F. M.; Jacinto, Manuel L.; Prudêncio, Cristina; Noronha, João PauloThe search for alternative and effective therapies to fight cancer is one of the main goals of the pharmaceutical industry. Recently, ionic liquids (ILs) have emerged as potential therapeutic agents with antitumor properties. The goal of this study was to synthesize and evaluate the bioactivity of different ILs coupled with the active pharmaceutical ingredient (API) valproate (VPA) as an antitumor agent. The to...
Synthesis and Biological Evaluation of Amphotericin B Formulations Based on Org...
Ferraz, Ricardo; Santarém, Nuno; Santos, Andreia F. M.; Jacinto, Manuel L.; Cordeiro-da-Silva, Anabela; Prudêncio, Cristina; Noronha, João PauloFunding text This research was funded by the project NORTE-01-0145-FEDER-000012, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). This work was also supported by the Associate Laboratory for Green Chemistry LAQV financed by national funds from FCT/MCTES (UIDB/50006/2020, UIDP/50006/2020 ...
Ferrocene-Based Porous Organic Polymer (FPOP)
Petrovski, Zeljko; Moreira, Mateus P.; Santos, Andreia F. M.; Freitas, Sunny K. S.; Jordão, Noémi; Maia, Renata A.; Nunes, Ana V. M.; Branco, Luis C.This study was funded in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001 and FCT-CAPES project (2019–2020). The authors also thank the funding agencies FAPERJ, CNPq and Fundação para a Ciência e Tecnologia (PEst-C/LA0006/2013, RECI/BBBBQB/0230/2012 as well as “SunStorage—Harvesting and storage of solar energy”, with reference POCI-01-0145-FEDER-016387. The...
Ionic Systems and Nanomaterials as Antiseptic and Disinfectant Agents for Surfa...
Faisca, Francisco; Filipe, Luis; Petrovski, Zeljko; Santos, Miguel M.; Gago, Sandra; Branco, Luis C.UIDB/50006/2020 POCI-01-0145-FEDER-007265 PTDC/QUI-QOR/32406/2017 MAR-02.01.01-FEAMP-0042-INOVA4AQUA; Antiseptics and disinfectants are extensively used for a variety of topical and hard-surface applications. A wide variety of biocides as active chemical agents is found in these products, including alcohols, phenols, iodine, and chlorine. Many of these active agents demonstrate broad-spectrum antimicrobial acti...
Ionic Liquids Based on Oxidoperoxido-Molybdenum(VI) Complexes with a Chelating ...
Petrovski, Zeljko; Antunes, Margarida M.; Mendo, Ana Soraia de Oliveira; Cabrita, Luís; Gonçalves, Isabel S.; Valente, Anabela A.UID/QUI/50006/2019 UID/Multi/04378/2019 UIDB/50011/2020 UIDP/50011/2020; Ionic oxidoperoxido-molybdenum(VI) complexes of the type [Cat][MoO(O2)2(pic)], with pic = N,O-chelated picolinate ligand and Cat = monocation, were prepared in high yields (82–95%) from the precursor complex [H3O][MoO(O2)2(pic)] via [H]+ cation exchange for 1-ethyl-3-methylimidazolium [EMIM]+, 1-butyl-3-methylimidazolium [BMIM]+, 1-octyl-3...
Novel biocompatible ionic liquids based on gluconate anion
Costa, Alexandra; Forte, Andreia; Zalewska, Karolina; Tiago, Gonçalo; Petrovski, Zeljko; Branco, Luís C.A sustainable organic synthetic methodology for the preparation of novel biocompatible ionic liquids (ILs) based on gluconate anion has been developed. Four functionalized methylimidazolium cations were efficiently combined with gluconic acid by acid-base neutralization reactions. All salts were obtained as RTILs in high yields (92–98%) and in high purity levels. Proton Nuclear Magnetic Resonance (1H NMR) studi...
Antitumor Activity of Ionic Liquids Based on Ampicillin
Ferraz, Ricardo; Costa-Rodrigues, João; Fernandes, Maria H.; Santos, Miguel; Marrucho, I. M.; Rebelo, Luis P. N.; Prudêncio, CristinaSignificant antiproliferative effects against various tumor cell lines were observed with novel ampicillin salts as ionic liquids. The combination of anionic ampicillin with appropriate ammonium, imidazolium, phosphonium, and pyridinium cations yielded active pharmaceutical ingredient ionic liquids (API-ILs) that show potent antiproliferative activities against five different human cancer cell lines: T47D (brea...