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PSORIASIS TREATMENT IN PEDIATRIC AGE – PART I: TOPICAL TREATMENT
Cruz, Maria João; Magina, Sofia; Baudrier, Teresa; Azevedo, FilomenaPsoriasis is a chronic inflammatory disorder, multisystem and immunologically mediated. Approximately one third of adults refer the age of onset before 16, representing about 4% of all dermatoses seen in pediatric age. The majority of cases are mild and adequately managed with topical medications. A minor subset of children present with severe, rapidly evolving disease that requires systemic therapy. The use of...
FUROSEMIDE-INDUCED BULLOUS PEMPHIGOID
Cruz, Maria João; Baudrier, Teresa; Ferreira, Olga; Barreto, Filomena; Azevedo, FilomenaBullous pemphigoid (BP) is an acquired autoimmune disease characterized by subepidermal vesicles and bullae. The etiology for BP is mostly idiopathic with the highest occurrence in elderly patients, however, it is now wellaccepted that BP can be triggered by or associated with physical stimuli, malignancies, other autoimmune disorders and drugs. Drug-induced BP is a very rare complication of systemic therapy wi...
NECROBIOTIC XANTHOGRANULOMA ASSOCIATED WITH GIANT CELL HEPATITIS
Ferreira, Olga; Mota, Alberto; Baudrier, Teresa; Rodrigues, Susana; Sarmento, José Alexandre; Pestana, José; Bettencourt, Herberto; Azevedo, FilomenaWe describe a 44-year-old woman with recurrent episodes of red eye, myalgias, hypercholesterolemia, hypocomplementemia, monoclonal gammopathy and giant cell hepatitis that was observed due to erythematoviola- ceous plaque on the right arm. Skin biopsy revealed necrobiotic xanthogranuloma. This case illustrates the importance of accurate characterization of skin lesions in the setting of a systemic disease with ...
THE RELEVANCE OF GRISEOGLUVIN IN THE TREATMENT OF TINEA CAPITIS IN PEDIATRIC AG...
Cruz, Maria João; Calistru, Ana; Baudrier, Teresa; Azevedo, Filomena; Mota, AlbertoTinea capitis is a superficial infection of the scalp caused by dermatophyte fungi, being nowadays the most common fungal infection in children. Griseofulvin remains as the gold standard treatment, however, in many coun- tries, the newer oral antifungal agents (terbinafine, itraconazole and fluconazole) appear to have efficacy and safety profiles similar to those of griseofulvin, allowing treatment courses of s...
UNCOMMON CAUSES OF LEG ULCERS AND THEIR MANAGEMENT
Cruz, Maria João; Baudrier, Teresa; Azevedo, FilomenaChronic wounds of the lower limbs are a major public healthcare problem affecting 1% of the adult po- pulation and 3-5% of people older than 65 years. In the last years this numbers are rising in the western population as a result of increased life expectancy and increased risk factors for atherosclerotic occlusion such as smoking, obesity and diabetes mellitus. This is very debilitating condition, which reduce...
PROLIDASE DEFICIENCY – A RARE CAUSE OF LEG ULCERS IN PEDIATRIC AGE
Cruz, Maria João; Mota, Alberto; Baudrier, Teresa; Silva, Elisa; Eloy, Catarina; Azevedo, FilomenaProlidase deficiency is a rare, autosomal recessive disease resulting from a mutation of the prolidase gene (PEPD) located on chromosome 19. The deficiency of this enzyme impairs proline recycling and consequently the synthesis of collagen. This defect may be asymptomatic or associated with different clinical manifestations, being the most frequently reported chronic skin ulcers, recurrent infections, hepatospl...
ERYTHROPOIETIC PROTOPORPHYRIA – A Family Study and Report of a Novel Mutation i...
Morais, Paulo; Mota, Alberto; Baudrier, Teresa; Ferreira, Olga; Trigo, Filipe; Cerqueira, Rita; Palmeiro, Aida; Tavares, Purificação; Azevedo, FilomenaErythropoietic protoporphyria (EPP) is a rare inherited disorder of heme biosynthesis caused in most patients by a deficient activity of the enzyme ferrochelatase (FECH), with a consequent accumulation of protoporphyrin (PP) in various tissues. We report a 16-year-old male (index case) with EPP characterized by acute episodes of painful photosensitivity in the photoexposed areas since his early infancy, permane...
Cutaneous adverse reaction to carbamazepine: unusual presentation.
Duarte, Ana Filipa; Baudrier, Teresa; Mota, Alberto; Azevedo, FilomenaBesides its use for the control of seizures, carbamazepine is being increasingly prescribed for neuropathic pain and depression, and this may explain the increased incidence of cutaneous drug reactions, namely Setevens-Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis associated with this drug. We report a case of a 42-year-old woman, medicated with levotyroxin for years and carbamazepine for fifteen days due t...