22 documents found, page 1 of 3
Randomized clinical study of injectable dextrin-based hydrogel as a carrier of ...
Machado, Alexandra; Pereira, Isabel; Costa, Filomena; Brandão, Ana; Pereira, José Eduardo; Maurício, Ana Colette; Santos, José Domingos; Amaro, InêsObjectives This study aimed to improve the performance and mode of administration of a glass-reinforced hydroxyapatite synthetic bone substitute, Bonelike by Biosckin® (BL®), by association with a dextrin-based hydrogel, DEXGEL, to achieve an injectable and moldable device named DEXGEL Bone. Methods Twelve participants requiring pre-molar tooth extraction and implant placement were enrolled in this study. BL® g...
Allogenic synovia-derived mesenchymal stem cells for treatment of equine tendin...
Reis, Inês Leal; Lopes, Bruna; Sousa, Patrícia; Sousa, Ana Catarina; Branquinho, Mariana; Caseiro, Ana Rita; Pedrosa, Sílvia Santos; Rêma, AlexandraTendon and ligament injuries are frequent in sport horses and humans, and such injuries represent a significant therapeutic challenge. Tissue regeneration and function recovery are the paramount goals of tendon and ligament lesion management. Nowadays, several regenerative treatments are being developed, based on the use of stem cell and stem cell-based therapies. In the present study, the preparation of equine...
Dextrin hydrogel loaded with a macroporous Bonelike® scaffold and dental pulp s...
Machado, A.; Pereira, Isabel; Pereira, José Eduardo; Maltez, Luís; Brandão, Ana; Alvites, Rui; Sousa, Ana Catarina; Branquinho, MarianaRegeneration of severe bone defects remains a challenge. A formulation of synthetic glass-reinforced hydroxyapatite bone substitute, Bonelike® Poro (BL®P), 250500 µm-diameter, with a dextrin-based hydrogel (HG), further loaded with human dental pulp stem cells (hDPSCs) with osteogenic differentiation ability, was tested for the management of critical-sized defects in an ovine model. Morphology, calcium release,...
Randomized clinical study of injectable dextrin-based hydrogel as a carrier of ...
Machado, Alexandra; Pereira, Isabel; Costa, Filomena; Brandão, Ana; Pereira, José Eduardo; Maurício, Ana Colette; Santos, José Domingos; Amaro, InêsThis study aimed to improve the performance and mode of administration of a glass-reinforced hydroxyapatite synthetic bone substitute, Bonelike by Biosckin® (BL®), by association with a dextrin-based hydrogel, DEXGEL, to achieve an injectable and moldable device named DEXGEL Bone.
Dextrin hydrogel loaded with a macroporous Bonelike® scaffold and dental pulp s...
Machado, Alexandra; Pereira, Isabel; Pereira, José Eduardo; Maltez, Luís; Brandão, Ana; Alvites, Rui; Sousa, Ana Catarina; Branquinho, MarianaRegeneration of severe bone defects remains a challenge. A formulation of synthetic glass-reinforced hydroxyapatite bone substitute, Bonelike® Poro (BL®P), 250–500 µm-diameter, with a dextrin-based hydrogel (HG), further loaded with human dental pulp stem cells (hDPSCs) with osteogenic differentiation ability, was tested for the management of critical-sized defects in an ovine model. Morphology, calcium release...
Regeneration of critical-sized defects, in a goat model, using a dextrin-based ...
Pereira, Isabel Sofia Melo; Pereira, José Eduardo; Maltez, Luís; Rodrigues, Alexandra; Rodrigues, Catarina; Oliveira, Manuela; Silva, Dina M.The development of injectable bone substitutes (IBS) have obtained great importance in the bone regeneration field, as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular topographies. In this scenario, the association of injectable hydrogels and bone graft granules is emerging as a well-established trend. Particularly, in situ forming hydrogels have ar...
Mesenchymal Stem Cells (MSCs) as a potential therapeutic Strategy in COVID-19 P...
Coelho, André; Alvites, Rui Damásio; Branquinho, Mariana Vieira; Guerreiro, Susana G.; Maurício, Ana ColetteIn 2019, an outbreak of an unknown coronavirus – SARS-CoV-2 – responsible for COVID-19 disease, was first reported in China, and evolved into a pandemic of huge dimensions and raised serious concerns for global health. The number of critical cases continues to increase dramatically, while vaccines and specific treatments are not yet available. There are several strategies currently being studied for the treatme...
Sheep Gait Biomechanics and the Assessment of Musculoskeletal Conditions: A Sys...
Silva, Rui; Dimas, Ivo Santos; Fernandez, Justin W.; Alves, Nuno; Morouço, Pedro; Maurício, Ana Colette; Veloso, António; Sandra, AmadoIn recent years, sheep have been reported as the ideal animal model to study osteoporosis, hence it is important to identify instruments, tools and ideal parameters needed to assess the effects of different treatments. In previous studies conducted in other animal models with osteoporosis, the most common parameters used for evaluation concerned primarily bone properties, such as the dual X-ray absorptiometry. ...
Long term performance evaluation of small-diameter vascular grafts based on pol...
Alexandre, Nuno; Amorim, Irina; Caseiro, Ana Rita; Pereira, Tiago; Alvites, Rui; Rêma, Alexandra; Gonçalves, Ana; Costa, Elisio; Santos-Silva, AliceThe functional and structural performance of a 5 cm synthetic small diameter vascular graft (SDVG) produced by the copolymerization of polyvinyl alcohol hydrogel with low molecular weight dextran (PVA/Dx graft) associated to mesenchymal stem cells (MSCs)-based therapies and anticoagulant treatment with heparin, clopidogrel and warfarin was tested using the ovine model during the healing period of 24 weeks. The ...
Dynamic feet distance: a new functional assessment during treadmill locomotion ...
Diogo, Camila Cardoso; Costa, Luís Maltez da; Pereira, José Eduardo; Filipe, Vítor; Couto, Pedro Alexandre; Magalhães, Luís Gonzaga MendesOf all the detrimental effects of spinal cord injury (SCI), one of the most devastating is the disruption of the ability to perform functional movement. Very little is known on the recovery of hindlimb joint kinematics after clinically-relevant contusive thoracic lesion in experimental animal models. A new functional assessment instrument, the dynamic feet distance (DFD) was used to describe the distance betwee...