9 documents found, page 1 of 1
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDAL...
Bousquet, J.; Melén, E.; Haahtela, T.; Koppelman, G. H.; Togias, A.; Valenta, R.; Akdis, C. A.; Czarlewski, W.; Rothenberg, M.; Valiulis, A.Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhiniti...
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDAL...
Bousquet, J.; Melén, E.; Haahtela, T.; Koppelman, G. H.; Togias, A.; Valenta, R.; Akdis, C. A.; Czarlewski, W.; Rothenberg, M.; Valiulis, A.Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhiniti...
ARIA 2016: Care pathways implementing emerging technologies for predictive medi...
Bousquet, J.; Hellings, P. W.; Agache, I.; Bedbrook, A.; Bachert, C.; Bergmann, K. C.; Bewick, M.; Bindslev-Jensen, C.; Bosnic-Anticevitch, S.The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and im...
Scaling up strategies of the chronic respiratory disease programme of the Europ...
Bousquet, J.; Farrell, J.; Crooks, G.; Hellings, P.; Bel, E. H.; Bewick, M.; Chavannes, N. H.; de Sousa, J. Correia; Cruz, A. A.; Haahtela, T.; Joos, G.Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies C...
Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transth...
Coelho, T.; Merlini, G.; Bulawa, C.; Fleming, J.; Judge, D.; Kelly, J.; Maurer, M.; Planté-Bordeneuve, V.; Labaudinière, R.; Mundayat, R.; Riley, S.Transthyretin (TTR) transports the retinol-binding protein-vitamin A complex and is a minor transporter of thyroxine in blood. Its tetrameric structure undergoes rate-limiting dissociation and monomer misfolding, enabling TTR to aggregate or to become amyloidogenic. Mutations in the TTR gene generally destabilize the tetramer and/or accelerate tetramer dissociation, promoting amyloidogenesis. TTR-related amyloi...
ARIA 2016: care pathways implementing emerging technologies for predictive medi...
Bousquet, J.; Hellings, P. W.; Agache, I.; Bedbrook, A.; Bachert, C.; Bergmann, K. C.; Bewick, M.; Bindslev-Jensen, C.; Bosnic-Anticevitch, S.The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and im...
Recommendations for assessing patient-reported outcomes and health-related qual...
Baiardini, I.; Braido, F.; Bindslev-Jensen, C.; Bousquet, P. J.; Brzoza, Z.; Canonica, G. W.; Compalati, E.; Fiocchi, A.; Fokkens, W.The aim of this Global Allergy and Asthma European Network (GA2LEN) consensus report is to provide recommendations and suggestions for assessing patient-reported outcomes (PROs) including health-related quality of life in patients with urticaria. We recommend that PROs should be used both in clinical trials and routine practice for the evaluation of urticaria patients. We suggest that PROs should be considered ...
Specific recommendations for PROs and HRQoL assessment in allergic rhinitis and...
Braido, F.; Bousquet, P. J.; Brzoza, Z.; Canonica, G. W.; Compalati, E.; Fiocchi, A.; Fokkens, W.; Gerth van Wijk, R.; La Grutta, S.; Lombardi, C.The GA2LEN taskforce on Patient-Reported Outcomes (PROs) and Health-Related Quality of Life (HRQoL) published in 2009 a position paper concerning PROS and HRQoL assessment in clinical trials on allergy. Because of the specificity of this topic in asthma and rhinitis, specific recommendations are needed. The aim of this position paper is to define PROs and their meaning in asthma and rhinitis research, explore t...
Recommendations for assessing Patient-Reported Outcomes and Health-Related qual...
Baiardini, I.; Bousquet, P. J.; Brzoza, Z.; Canonica, G. W.; Compalati, E.; Fiocchi, A.; Fokkens, W.; Gerth van Wijk, R.; La Grutta, S.; Lombardi, C.The aim of this GA2LEN consensus report is to provide recommendations for Patient-Reported Outcomes evaluation in clinical trials for allergic diseases, which constitute a global health problem in terms of physical, psychological, economic and social impact. During the last 40 years PROs have gained large consideration and use in the scientific community, in order to gain a better understanding of patients’ sub...