58 documents found, page 1 of 6

Gadolinium and gadoteric acid exposure induce long-term down-regulation in eryt...

Background: Gadolinium-based contrast agents (GBCA) differ in their potential to release gadolinium [Gd (III)], known to be toxic. Gadoteric acid (Gd-DOTA) is a macrocyclic GBCA, with a more stable structure. After GBCA exposure, Gd (III) retention in red blood cells (RBC) and kidney has been reported [1,2]. Nephrogenic systemic fibrosis, a severe condition found in renal disease patients exposed to GBCA, is as...

Short-term and long-term effects of gadolinium and gadoteric acid exposure on r...

Background: There are currently concerns about the safety of gadolinium-based contrast agents (GBCA), as they can release gadolinium [Gd (III)], known to be toxic. Free Gd (III) deposition at different organs, as kidney and liver, has been reported [1,2]. We found that Gd (III) promotes inflammation and fibrosis in proximal tubular cells [3]. GBCA with macrocyclic structure, as gadoteric acid (Gd-DOTA), are con...

Subpopulations of High-Density Lipoprotein: Friends or Foes in Cardiovascular D...

Dyslipidemia is a major traditional risk factor for cardiovascular disease (CVD) in chronic kidney disease (CKD) patients, although the altered lipid profile does not explain the number and severity of CVD events. High-density lipoprotein (HDL) is a heterogeneous (size, composition, and functionality) population of particles with different atherogenic or atheroprotective properties. HDL-cholesterol concentratio...

Linkage of typically cytosolic peroxidases to erythrocyte membrane - A possible...

Hereditary Spherocytosis (HS) is a non-immune hemolytic anemia associated to oxidative stress (OS), namely to the linkage of cytosolic antioxidant enzymes to the erythrocyte membrane. Our aims were to evaluate erythrocyte OS changes and the membrane linkage of peroxiredoxin 2 (Prx2), glutathione peroxidase (GPx) and catalase (CAT) in unsplenectomized (unspl) and splenectomized (spl) HS patients and to search fo...

Effects of statins therapy on LDL subfractions and inflammation in end-stage re...

The protective role of adiponectin for lipoproteins in end-stage renal disease ...

Cardiovascular disease (CVD) events are the main causes of death in end-stage renal disease (ESRD) patients on dialysis. The number and severity of CVD events remain inappropriate and difficult to explain by considering only the classic CVD risk factors. Our aim was to clarify the changes and the relationship of lipoprotein subfractions with other CVD risk factors, namely, body mass index (BMI) and adipokines, ...

Resistência à terapêutica com eritropoietina humana recombinante em doentes hem...

Com o objectivo de clarificar o mecanismo de resistência à terapêutica com eritropoietina humana recombinante (EPOhr) em doentes hemodializados, estudamos alterações a ela associada, com particular interesse na inflamação, activação leucocitária, ciclo do ferro, stress oxidativo e lesão eritrocitária. Foram estudados 63 doentes renais crónicos (DRC) em hemodiálise e terapêutica com EPOhr (32 respondedores e 31 ...

Machine learning in prediction of vulnerable or resilient end-stage renal disea...

Hepcidin-25 and treatment with erythropoiesis stimulating agents are independen...

Comparison of immunohematological profile between endurance- and power-oriented...

There is general perception that elite athletes are highly susceptible to changes in immunohematological profile. The objective of this study was to compare immunohematological parameters of elite athletes of different aerobic and muscular strength sports and analyze changes over 2 months. Sixteen judoists and 14 swimmers were evaluated 2 months before (M1) and immediately prior to competition (M2). Hemogram an...