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In vitro metabolism of copalic and kaurenoic acids in rat and human liver micro...

Mauro,Mariana; Silva,Rodrigo Moreira da; Campos,Michel Leandro de; Bauermeister,Anelize; Lopes,Norberto Peporine; Moraes,Natalia Valadares de

Copalic (CA) and kaurenoic (KA) acids are the main diterpenes found in the oleoresin extracted from the copaiba tree (Copaifera sp). This study aimed to characterize the metabolism of CA and KA in rat and human liver microsomes using liquid chromatography with tandem mass spectrometry (LC-MS/MS). The in vitro assays showed deviations from the Michaelian kinetics in the metabolism of CA and KA. Putative metaboli...

Date: 2021   |   Origin: Oasisbr
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