4 documents found, page 1 of 1
Extracorporeal light chains removal - What role does this play in 2020?
Coelho,Inês; Ferreira,Hugo; Chuva,Teresa; Paiva,Ana; Maximino,JoséMultiple Myeloma (MM) is characterized by a neoplastic proliferation of plasma cell clones producing monoclonal immunoglobulin. Manifestations of the disease are heterogenous and include dialysis-requiring acute kidney injury (AKI) caused mainly by cast nephropathy (CN). It is known that early and rapid decrease in serum free light chains (sFLC) levels is particularly important for renal recovery, which has led...
Gemcitabine-associated thrombotic microangiopathy - a role for eculizumab?
Chuva,Teresa; Ferreira,Ana; Maximino,José; Henrique,Rui; Paiva,Ana; Loureiro,AlfredoGemcitabine-associated thrombotic microangiopathy (gTMA) is a rare entity that is usually associated with a poor prognosis, with loss of kidney function and often death. The management of this syndrome includes discontinuation of the drug. Other approaches have been tried, with no proven efficacy and inconsistent results, such as glucocorticoids, intravenous immunoglobulin, plasma infusion and rituximab. Drug-i...
Multiple myeloma and high cut-off haemodialysis: On the right track for better ...
Chuva,Teresa; Maximino,José; Barbosa,Joselina; Santos,Paulo; Silva,Sandra; Paiva,Ana; Baldaia,Jorge; Santos,Teresa; Loureiro,AlfredoBackground: Acute kidney injury secondary to cast nephropathy is a common complication of multiple myeloma. Extracorporeal light chain elimination by high cut-off haemodialysis has been described as an adjuvant to effective chemotherapy to limit free light chain toxicity. The purpose of this study was to evaluate the impact of high cut-off haemodialysis and bortezomib-based chemotherapy on renal function recove...
Cancer and End-Stage Kidney Disease: A Death Sentence?
Chuva,Teresa; Maximino,José; Barbosa,Joselina; Henrique,Rui; Silva,Sandra; Santos,Paulo; Loureiro,AlfredoBackground: End-stage kidney disease is associated with considerable morbidity and mortality, a feature that is shared with malignant neoplasms. Hence, patients with the cumulative effect of these two diseases frequently give rise to the question of whether dialysis should be implemented. The primary goal of this study was to characterize the clinical progression and evaluate the outcome of a group of oncology ...