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Health-related quality of life at 5 years of age for children born very preterm...

Kim, SW; Tian, X; Andronis, L; Maier, RF; Varendi, H; Seppänen, A-V; Siljehav, V; Draper, ES; Zeitlin, J; Petrou, S; Seppänen, AV; El Rafei, R

Background: This study aimed to investigate the health-related quality of life (HRQoL) at 5 years of age of European children born very preterm across multi-dimensional outcomes by presence and severity of congenital anomalies. Methods: The study used data from a European cohort of children born very preterm (<32 weeks of gestation) and followed up to 5 years of age (N = 3493). Multilevel Ordinary Least Squares...


Motor-related health care for 5-year-old children born extremely preterm with m...

Costa, R; Aubert, AM; Seppänen, A-V; Ådén, U; Sarrechia, L; Zemlin, M; Cuttini, M; Männamaa, M; Pierrat, V; van Heijst, A; Barros, H; Johnson, S

Aim: To (1) determine the proportion of 5-year-old children born extremely preterm (EPT) with movement difficulties including cerebral palsy (CP) and the proportion of these children receiving motor-related health care (MRHC), and (2) describe factors associated with receiving MRHC. Method: Children born before 28 weeks’ gestation in 2011 to 2012 in 11 European countries were assessed with the Movement Assessme...


Neonatal Morbidity and Mortality in Advanced Aged Mothers-Maternal Age Is Not a...

Nourkami-Tutdibi, N; Tutdibi, E; Faas, T; Wagenpfeil, G; Draper, ES; Johnson, S; Cuttini, M; Rafei, RE; Seppänen, AV; Mazela, J; Maier, RF; Nuytten, A

Background: As childbearing is postponed in developed countries, maternal age (MA) has increased over decades with an increasing number of pregnancies between age 35–39 and beyond. The aim of the study was to determine the influence of advanced (AMA) and very advanced maternal age (vAMA) on morbidity and mortality of very preterm (VPT) infants. Methods: This was a population-based cohort study including infants...


Variability in Very Preterm Stillbirth and In-Hospital Mortality Across Europe

Draper, ES; Manktelow, BN; Cuttini, M; Maier, RF; Fenton, AC; Van Reempts, P; Bonamy, AK; Mazela, J; Bᴓrch, K; Koopman-Esseboom, C; Varendi, H

BACKGROUND AND OBJECTIVE: Stillbirth and in-hospital mortality rates associated with very preterm births (VPT) vary widely across Europe. International comparisons are complicated by a lack of standardized data collection and differences in definitions, registration, and reporting. This study aims to determine what proportion of the variation in stillbirth and in-hospital VPT mortality rates persists after adju...


Variation in term birth weight across European countries affects the prevalence...

Zeitlin, J; Bonamy, AK; Piedvache, A; Cuttini, M; Barros, H; Van Reempts, P; Mazela, J; Jarreau, PH; Gortner, L; Draper, ES; Maier, RF

Aim: This study assessed the prevalence of small for gestational age (SGA) among very preterm (VPT) infants using national and European intrauterine references. Methods. We generated country‐specific and common European intrauterine growth references for 11 European countries, according to Gardosi's approach and Hadlock's foetal growth model, using national data on birthweights by sex. These references were app...


Association of Short Antenatal Corticosteroid Administration-to-Birth Intervals...

Norman, M; Piedvache, A; Børch, K; Huusom, LD; Bonamy, AK; Howell, EA; Jarreau, PH; Maier, RF; Pryds, O; Toome, L; Varendi, H; Weber, T; Wilson, E

Administration-to-birth intervals of antenatal corticosteroids (ANS) vary. The significance of this variation is unclear. Specifically, to our knowledge, the shortest effective administration-to-birth interval is unknown. Objective:To explore the associations between ANS administration-to-birth interval and survival and morbidity among very preterm infants. Design, Setting, and Participants: The Effective Perin...


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