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Methylphenidate and P300 in attention deficit hyperactivity disorder: A systema...

Barroso, Beatriz C. R.; Mendonça, Fabiana; Mazer, Prune; Prata, Catarina; Pinto, Joana O.; Mazer, Prune; Pinto, Joana O

Methylphenidate (MPH) is a stimulant medicine often used to treat attention deficit hyperactivity disorder (ADHD), as it may positively affect behaviour and brain activity. This work aims to systematise the current literature about the effects of MPH on the amplitude of P300 in individuals with ADHD. A systematic review and meta-analysis of empirical studies measuring P300 amplitude and comparing MPH administra...


How distinct Autism and Schizotypal trait dimensions influence neural predictiv...

Mazer, Prune; Pasion, Rita; Fontes, Melissa; Pires, Cristiana; Silveira, Celeste; Fernando Ferreira-Santos; Mazer, Prune

The Predictive Processing (PP) framework provides a compelling model for understanding the neural mechanisms underlying autism spectrum disorders (ASD) and schizophrenia spectrum disorders (SSD). In this study, we developed visual and auditory oddball tasks with two levels of target detection difficulty to effectively elicit event-related potential (ERP) components. A total of 122 participants from the communit...


Does attention to cardiac sensations modulate heartbeat-evoked potentials even ...

Braga, Patrícia Vilela; Vieira, Beatriz; Carina, Fernandes; Barbosa, Fernando; Santos, Fernando Ferreira; Pereira, Mariana R.; Rocha, Nuno Barbosa

Heartbeat-evoked potentials (HEP) have been shown to be modulated by attentional focus (cardiac vs. exteroceptive attention), suggesting that HEP are a neural correlate of interoceptive prediction errors. However, this effect has not been consistently replicated, and differences in cognitive effort when contrasting interoceptive vs. exteroceptive attention may be a confounding factor. We devised a modified Hear...


Systematic review and meta-analysis of the visual mismatch negativity in schizo...

Mazer, Prune; Carneiro, Fabio; Domingo, Juan; Pasion, Rita; Silveira, Celeste; Ferreira-Santos, Fernando

Mismatch negativity (MMN) is an event-related potential component automatically elicited by events that violate predictions based on prior events. To elicit this component, researchers use stimulus repetition to induce predictions, and the MMN is obtained by subtracting the brain response to rare or unpredicted stimuli from that of frequent stimuli. Under the Predictive Processing framework, one increasingly po...


Autistic traits and event-related potentials in the general population: A scopi...

Mazer, Prune; Garcez, Helena; Macedo, Inês; Pasion, Rita; Silveira, Celeste; Sempf, Frederieke; Ferreira-Santos, Fernando

Differences in short and long-latency Event-Related Potentials (ERPs) can help us infer abnormalities in brain processing, considering early and later stages of stimuli processing across tasks and conditions. In autism research, the adult population remains largely understudied compared to samples at early stages of development. In this context, this scoping review briefly summarises what has been described in ...


Cardiac interoceptive processing across psychopathy dimensions: evidence from t...

Campos, Carlos; Sá, Catarina; Mazer, Prune; Pasion, Rita; Garcez, Helena; Paiva, Tiago O.; Braga, Patrícia Vilela; Rocha, Nuno Barbosa

Psychopathy is a multidimensional personality structure encompassing interpersonal, affective, and behavioral traits. Interoception (ability to perceive and subjectively experience inner bodily states) may be a putative mechanism underlying the etiological pathways of psychopathy. Individual differences in interoceptive processing across psychopathy dimensions may interfere with the ability to perceive somatic ...


Refining the link between psychopathy, antisocial behavior, and empathy: a meta...

Campos, Carlos; Pasion, Rita; Azeredo, Andreia; Eduarda, Ramião; Mazer, Prune; Machado, Inês; Barbosa, Fernando

The current meta-analysis included 431 records (N= 123,414) to comprehensively explore the complex interaction between psychopathy, antisocial behavior, and empathy. First, empathy domains (cognitive and affective) were used to provide critical insights for distinguishing antisocial behavior from psychopathy. Cognitive empathy was more impaired in antisocial groups (gcognitive= -.40; gaffective= -.11), while hi...


Refining the link between psychopathy, antisocial behavior, and empathy: A meta...

Campos, Carlos; Pasion, Rita; Azeredo, Andreia; Ramião, Eduarda; Mazer, Prune; Macedo, Inês; Barbosa, Fernando

The current meta-analysis includes 477 records (N = 142,692) and comprehensively explores the complex interplay between psychopathy, antisocial behavior, and empathy. First, empathy domains (cognitive and affective) were used to dissociate antisocial behavior from psychopathy. Cognitive empathy was more impaired in antisocial groups (gcognitive = -0.43; gaffective = -0.11), while samples scoring higher in psych...


Abnormal habituation of the auditory event-related potential P2 component in pa...

Mazer, Prune; Macedo, Inês; Paiva, Tiago O.; Ferreira-Santos, Fernando; Paison, Rita; Barbosa, Fernando; Almeida, Pedro; Silveira, Celeste

Auditory event-related potentials (ERP) may serve as diagnostic tools for schizophrenia and inform on the susceptibility for this condition.Particularly, the examination of N1 and P2 components of the auditory ERP may shed light on the impairments of information processing streams in schizophrenia. However, the habituation properties (i.e., decreasing amplitude with the repeated presentation of an auditory stim...


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