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Dysregulation of autophagy and stress granule-related proteins in stress-driven...
Silva, Joana Margarida Gonçalves Mota; Rodrigues, Sara; Marques, Maria Belém Sousa Sampaio; Gomes, Patrícia; Carvalho, Andreia Alexandra NevesImbalance of neuronal proteostasis associated with misfolding and aggregation of Tau protein is a common neurodegenerative feature in Alzheimer's disease (AD) and other Tauopathies. Consistent with suggestions that lifetime stress may be an important AD precipitating factor, we previously reported that environmental stress and high glucocorticoid (GC) levels induce accumulation of aggregated Tau; however, the m...
Date: 2019
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Origin: RepositóriUM - Universidade do Minho