5 documents found, page 1 of 1
Synergic effect of allopurinol in combination with nitro-heterocyclic compounds...
Mazzeti, Ana Lia; Diniz, Lívia de Figueiredo; Gonçalves, Karolina Ribeiro; WonDollinger, Ruan Schott; Martins, Tassiane Assíria Fontes; Ribeiro, IsabelaCombination therapy has gained attention as a possible strategy for overcoming the limitations of the present therapeutic arsenal for Chagas disease. The aim of this study was to evaluate the effect of allopurinol in association with nitroheterocyclic compounds on infection with the Y strain of Trypanosoma cruzi. The in vitro effect of allopurinol plus benznidazole or nifurtimox on intracellular amastigotes in ...
Ravuconazole self-emulsifying delivery system : in vitro activity against Trypa...
Spósito, Pollyanna Álvaro; Mazzeti, Ana Lia; Faria, Caroline de Oliveira; Urbina, Julio Alberto; Lana, Gwenaelle Elza Nathalie PoundSelf-emulsifying drug delivery systems (SEDDSs) are lipid-based anhydrous formulations composed of an isotropic mixture of oil, surfactant, and cosurfactants usually presented in gelatin capsules. Ravuconazole (Biopharmaceutics Classification System [BCS] Class II) is a poorly water-soluble drug, and a SEDDS type IIIA was designed to deliver it in a predissolved state, improving dissolution in gastrointestinal ...
Chagas cardiomyopathy : the potential effect of benznidazole treatment on diast...
Santos, Fabiane Matos dos; Mazzeti, Ana Lia; Caldas, Sérgio; Gonçalves, Karolina Ribeiro; Lima, Wanderson Geraldo de; Torres, Rosália MoraisCardiac involvement represents the main cause of mortality among patients with Chagas disease, and therelevance of trypanocidal treatment to improving diastolic dysfunction is still doubtful. In the presentstudy, we used a canine model infected with the benznidazole-sensitive Berenice-78 Trypanosoma cruzistrain to verify the efficacy of an etiologic treatment in reducing the parasite load and ameliorating cardi...
Chagas cardiomyopathy : the potential effect of benznidazole treatment on diast...
Santos, Fabiane Matos dos; Mazzeti, Ana Lia; Caldas, Sérgio; Gonçalves, Karolina Ribeiro; Lima, Wanderson Geraldo de; Torres, Rosália MoraisCardiac involvement represents the main cause of mortality among patients with Chagas disease, and therelevance of trypanocidal treatment to improving diastolic dysfunction is still doubtful. In the presentstudy, we used a canine model infected with the benznidazole-sensitive Berenice-78 Trypanosoma cruzistrain to verify the efficacy of an etiologic treatment in reducing the parasite load and ameliorating cardi...
Benznidazole and Posaconazole in experimental Chagas disease: positive interact...
Diniz, Lívia de Figueiredo; Urbina, Julio Alberto; Andrade, Isabel Mayer de; Mazzeti, Ana Lia; Martins, Tassiane Assíria Fontes; Caldas, Ivo SantanaBackground: Current chemotherapy for Chagas disease is unsatisfactory due to its limited efficacy, particularly in the chronic phase, with frequent side effects that can lead to treatment discontinuation. Combined therapy is envisioned as an ideal approach since it may improve treatment efficacy whilst decreasing toxicity and the likelihood of resistance development. We evaluated the efficacy of posaconazole in...