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Global variation in lipoprotein/a levels among patients with coronary heart dis...

Barkas, Fotios; Brandts, Julia; De Bacquer, Dirk; Jennings, Catriona; De Backer, Guy G.; Kotseva, Kornelia; Ryden, Lars; Lip, Gregory Y. H.

Background Lipoprotein(a) [Lp(a)] is a common risk factor for atherosclerotic cardiovascular disease, potentially more atherogenic per particle than low-density lipoprotein. An estimated 1.5 billion individuals globally have elevated levels ≥125 nmol/L, considered as a risk-enhancing threshold. Although Lp(a) levels vary by ethnicity, ongoing trials of novel therapies in predominantly secondary prevention patie...


Frequency of residual combined dyslipidemia and hypertriglyceridemia in patient...

Santos, Raul D.; Ray, Kausik K.; De Bacquer, Dirk; Jennings, Catriona; Kotseva, Kornelia; Rydén, Lars; Lip, Gregory Y. H.; Erlund, Iris; Ganly, Sandra

Background and aims: Hypertriglyceridemia (HTG) is independently associated with risk of atherosclerotic events, even when LDL-cholesterol levels appear controlled. This INTERASPIRE study determined the frequency of HTG and residual combined dyslipidemia and their related factors in patients with coronary heart disease (CHD) from 13 countries across six World Health Organization (WHO) regions. Methods: Particip...


Variation in secondary prevention of coronary heart disease: the INTERASPIRE study

McEvoy, John William; Jennings, Catriona; Kotseva, Kornelia; De Bacquer, Dirk; De Backer, Guy; Erlund, Iris; Vihervaara, Terhi; Lip, Gregory Y H

Background and aims: INTERASPIRE is an international study of coronary heart disease (CHD) patients, designed to measure if guideline standards for secondary prevention and cardiac rehabilitation are being achieved in a timely manner. Methods: Between 2020 and 2023, adults hospitalized in the preceding 6-24 months with incident or recurrent CHD were sampled in 14 countries from all 6 World Health Organization r...


Decentralization and integration of advanced cardiac care for the world’s poore...

Klassen, Sheila L.; Okello, Emmy; Ferrer, Jose M. E.; Alizadeh, Faraz; Barango, Prebo; Chillo, Pilly; Chimalizeni, Yamikani; Dagnaw, Wubaye Walelgne

Rheumatic and congenital heart disease, cardiomyopathies, and hypertensive heart disease are major causes of suffering and death in low- and lower middle-income countries (LLMICs), where the world's poorest billion people reside. Advanced cardiac care in these counties is still predominantly provided by specialists at urban tertiary centers, and is largely inaccessible to the rural poor. This situation is due t...


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