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EULAR recommendations for the management of rheumatoid arthritis with synthetic...
Smolen, Josef S.; Landewé, Robert B. M.; Bergstra, Sytske Anne; Kerschbaumer, Andreas; Sepriano, Alexandre; Aletaha, Daniel; Caporali, RobertoObjectives: To provide an update of the EULAR rheumatoid arthritis (RA) management recommendations addressing the most recent developments in the field. Methods: An international task force was formed and solicited three systematic literature research activities on safety and efficacy of disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids (GCs). The new evidence was discussed in light of the last...
Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation...
Lemos, Henrique Paula; Grespan, Renata; Manfredo Vieira, Silvio; Cunha, Thiago Mattar; Verri, Waldiceu A.; Fernandes, Karla S.; Souto, Fabrício OliveiraIL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin enhances the IL-23/IL-17-induced neutrophil migration in a murine model of RA by inhibiting IL-12 and IFN γ production. Methylated BSA (mBSA) and IL-23-induced neutrophil migration was inhibited by anti-IL-23 and anti-IL-...
GO-DACT : a phase 3b randomised, double-blind, placebo-controlled trial of GOli...
Vieira De Sousa, Elsa Cristina; Alves, Pedro; Rodrigues, Ana M.; Teixeira, Filipa; Tavares Costa, José; Bernardo, Alexandra; Pimenta, SofiaObjectives: To assess the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy in psoriatic arthritis (PsA) dactylitis. Methods: Multicentre, investigator-initiated, randomised, double-blind, placebo-controlled, parallel-design phase 3b trial in 11 Portuguese rheumatology centres. Patients with PsA along with active dactylitis and naive to MTX and biologic disease-modifying antirh...
Guidelines for the use of flow cytometry and cell sorting in immunological stud...
Cossarizza, Andrea; Chang, Hyun‐Dong; Radbruch, Andreas; Acs, Andreas; Adam, Dieter; Adam‐Klages, Sabine; Agace, William W.; Aghaeepour, NimaThese guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human...
Synovial tissue research : a state-of-the-art review
Orr, Carl; Vieira de Sousa, Elsa Cristina; Boyle, David L.; Buch, Maya H.; Buckley, Christopher D.; Cañete, Juan D.; Catrina, Anca I.The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synov...