3 documents found, page 1 of 1
Type I IFN inhibits alternative macrophage activation during mycobacterium tube...
Moreira-Teixeira, Lúcia; Sousa, Jeremy Nicolas Carvalho; McNab, Finlay W.; Torrado, Egídio; Cardoso, Filipa; Machado, Henrique; Castro, FláviaTuberculosis causes ∼1.5 million deaths every year, thus remaining a leading cause of death from infectious diseases in the world. A growing body of evidence demonstrates that type I IFN plays a detrimental role in tuberculosis pathogenesis, likely by interfering with IFN-γ–dependent immunity. In this article, we reveal a novel mechanism by which type I IFN may confer protection against Mycobacterium tuberculos...
Type I IFN induces IL-10 production in an IL-27-independent manner and blocks r...
McNab, Finlay W.; Ewbank, John; Howes, Ashleigh; Teixeira, Lucia de Fatima Moreira; Martirosyan, Anna; Ghilardi, Nico; Saraiva, Margarida; O’Garra, AnneTuberculosis, caused by the intracellular bacterium Mycobacterium tuberculosis, currently causes ~1.4 million deaths per year, and it therefore remains a leading global health problem. The immune response during tuberculosis remains incompletely understood, particularly regarding immune factors that are harmful rather than protective to the host. Overproduction of the type I IFN family of cytokines is associate...
TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial...
McNab, Finlay W.; Ewbank, John; Rajsbaum, Ricardo; Stavropoulos, Evangelos; Martirosyan, Anna; Redford, Paul S.; Wu, Xuemei; Graham, Christine M.Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading cause of mortality and morbidity worldwide, causing ~1.4 million deaths per year. Key immune components for host protection during tuberculosis include the cytokines IL-12, IL-1, and TNF-a, as well as IFN-? and CD4(+) Th1 cells. However, immune factors determining whether individuals control infection or progress to active tuberculosis are in...