5 documents found, page 1 of 1
Structural Rigidification of N-Aryl-pyrroles into Indoles Active against Intrac...
Semenya, Dorothy; Touitou, Meir; Ribeiro, Camila Maringolo [UNESP]; Pavan, Fernando Rogerio [UNESP]; Pisano, Luca; Singh, Vinayak; Chibale, KellyMade available in DSpace on 2022-04-28T17:30:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-08; South African National Research Foundation-SARChI; University of London; South African Medical Research Council (SAMRC); South African Department of Science and Innovation; South African National Research Foundation; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); A series of indolyl-3-me...
Structural Rigidification of N-Aryl-pyrroles into Indoles Active against Intrac...
Semenya, Dorothy; Touitou, Meir; Ribeiro, Camila Maringolo [UNESP]; Pavan, Fernando Rogerio [UNESP]; Pisano, Luca; Singh, Vinayak; Chibale, KellyMade available in DSpace on 2022-04-28T18:27:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-13; South African National Research Foundation-SARChI; University of London; South African Medical Research Council (SAMRC); South African Department of Science and Innovation; South African National Research Foundation; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); A series of indolyl-3-me...
Structural Rigidification of N-Aryl-pyrroles into Indoles Active against Intrac...
Semenya, Dorothy; Touitou, Meir; Ribeiro, Camila Maringolo [UNESP]; Pavan, Fernando Rogerio [UNESP]; Pisano, Luca; Singh, Vinayak; Chibale, KellyMade available in DSpace on 2022-05-01T11:23:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-13; A series of indolyl-3-methyleneamines incorporating lipophilic side chains were designed through a structural rigidification approach and synthesized for investigation as new chemical entities against Mycobacterium tuberculosis (Mtb). The screening led to the identification of a 6-chloroindole analogue ...
Improving the Potency of N-Aryl-2,5-dimethylpyrroles against Multidrug-Resistan...
Touitou, Meir; Manetti, Fabrizio; Ribeiro, Camila Maringolo [UNESP]; Pavan, Fernando Rogerio [UNESP]; Scalacci, Nicolò; Zrebna, Katarina; Begum, NeeluMade available in DSpace on 2020-12-12T02:32:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-05-14; A series of N-phenyl-2,5-dimethylpyrrole derivatives, designed as hybrids of the antitubercular agents BM212 and SQ109, have been synthesized and evaluated against susceptible and drug-resistant mycobacteria strains. Compound 5d, bearing a cyclohexylmethylene side chain, showed high potency against M. t...
Synthesis and SAR evaluation of novel thioridazine derivatives active against d...
Scalacci, Nicol�; Brown, Alistair K.; Pavan, Fernando R. [UNESP]; Ribeiro, Camila M. [UNESP]; Manetti, Fabrizio; Bhakta, Sanjib; Maitra, ArundhatiMade available in DSpace on 2018-12-11T17:30:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01; Royal Society of Chemistry; The neuroleptic drug thioridazine has been recently repositioned as possible anti-tubercular drug. Thioridazine showed anti-tubercular activity against drug resistant mycobacteria but it is endowed with adverse side effects. A small library of thioridazine derivatives has bee...