4 documents found, page 1 of 1
A sulfated-polysaccharide fraction from seaweed gracilaria birdiae prevents nap...
Silva, Renan O.; Santana, Ana Paula M.; Carvalho, Nathalia S.; Bezerra, Talita S.; Oliveira, Camila B.; Damasceno, Samara Rodrigues BonfimAbstract: Red seaweeds synthesize a great variety of sulfated galactans. Sulfated polysaccharides (PLSs) from seaweed are comprised of substances with pharmaceutical and biomedical potential. The aim of the present study was to evaluate the protective effect of the PLS fraction extracted from the seaweed Gracilaria birdiae in rats with naproxen-induced gastrointestinal damage. Male Wistar rats were pretreated w...
Carvacryl acetate, a derivative of carvacrol, reduces nociceptive and inflammat...
Damasceno, Samara Rodrigues Bonfim; Oliveira, Francisco Rodrigo A.M.; Carvalho, Nathalia S.; Brito, Camila F.C.; Silva, Irismara S.Aims: The present study aimed to investigate the potential anti-inflammatory and anti-nociceptive effects of carvacryl acetate, a derivative of carvacrol, in mice. Main methods: The anti-inflammatory activity was evaluated using various phlogistic agents that induce paw edema, peritonitis model, myeloperoxidase (MPO) activity, pro and anti-inflammatory cytokine levels. Evaluation of antinociceptive activity was...
Anti-inflammatory and antinociceptive activity of epiisopiloturine, an imidazol...
Silva, Valdelânia G.; Silva, Renan O.; Damasceno, Samara Rodrigues Bonfim; Carvalho, Nathalia S.; Prudêncio, Rafael S.; Aragão, Karoline SabóiaThe aim of this study was to investigate the antinociceptive and anti-inflammatory activities of epiisopiloturine (1), an imidazole alkaloid found in the leaves of Pilocarpus microphyllus. The anti-inflammatory activity of 1 was evaluated using several agents that induce paw edema and peritonitis in Swiss mice. Paw tissue and peritoneal fluid samples were obtained to determine myeloperoxidase (MPO) activity or ...
Polysaccharide isolated from Agardhiella ramosissima : chemical structure and a...
Batista, Jalles A.; Dias, Eulina G.N.; Brito, Tarcisio V.; Prudêncio, Rafael S.; Silva, Renan O.; Ribeiro, Ronaldo A.; Souza, Marcellus Henrique L.P.The sulfated polysaccharide (PLS) fraction of Agardhiella ramosissima was characterized by microanalysis, infrared spectroscopy, NMR and gas–liquid-chromatography–mass-spectrometry. The main constituent of PLS was the carrageenan. The monosaccharide composition of the PLS showed galactose, 3,6- anhydrogalactose and 6-O-methylgalactose. The PLS (30 mg kg−1) significantly reduced the paw oedema induced by carrage...