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Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fissio...
Teixeira, Vitor; Medeiros, Tânia C.; Vilaça, Rita; Pereira, Andreia T.; Chaves, Susana Alexandra Rodrigues; Côrte-Real, Manuela; Moradas-Ferreira, PedroMitochondria function as the powerhouses of the cell for energy conversion through the oxidative phosphorylation process. Accumulation of dysfunctional mitochondria promotes a bioenergetic crisis and cell death by apoptosis. Yeast cells lacking Isc1p, an orthologue of mammalian neutral sphingomyelinase type 2, exhibit mitochondrial dysfunction and shortened lifespan associated with the accumulation of specific ...
Data: 2015
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Origem: RepositóriUM - Universidade do Minho