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Diabetes e o futuro do tratamento.

Medina, JL; Souto, S; Ferreira, J


Lipodystrophy defined by Fat Mass Ratio in HIV-infected patients is associated ...

Freitas, P; Carvalho, D; Santos, AC; Mesquita, J; Matos, MJ; Madureira, AJ; Martinez, E; Sarmento, A; Medina, JL

Introduction: Combined antiretroviral therapy (cART) in the treatment of HIV-1 infection has been associated with complications, including lipodystrophy, hyperlipidaemia, insulin resistance (IR) and diabetes.Aims: To compare the prevalence of glucose homeostasis disturbances and IR in HIV patients on cART according to the presence of lipodystrophy (defined clinically and by Fat Mass Ratio) and different pattern...


Central/peripheral fat mass ratio is associated with increased risk of hyperten...

Freitas, P; Carvalho, D; Santos, AC; Madureira, AJ; Xerinda, S; Martinez, E; Pereira, J; Sarmento, A; Medina, JL

The data on the risk of hypertension in human immunodeficiency virus (HIV)-infected patients, particularly in those with lipodystrophy, are controversial. The authors assessed the impact of lipodystrophy on hypertension in a cohort of HIV-infected adults receiving combination antiretroviral therapy. This was a cross-sectional study in which lipodystrophy (clinically and fat mass ratio [FMR]-defined), blood pres...


Prevalence of obesity and its relationship to clinical lipodystrophy in HIV-inf...

Freitas, P; Carvalho, D; Santos, AC; Matos, MJ; Madureira, AJ; Marques, R; Martinez, E; Sarmento, A; Medina, JL

Background: Combination antiretroviral therapy (cART) is associated with lipodystrophy (lipoatrophy and lipoaccumulation) and several metabolic abnormalities that together can contribute to an increased cardiovascular risk. The aim of this study was to evaluate the prevalence of obesity in patients on cART according to the presence of clinical lipodystrophy (CL) and to analyze factors associated with obesity. M...


Impact of Lipodystrophy on the prevalence and components of metabolic syndrome ...

Freitas, P; Carvalho, D; Souto, S; Santos, AC; Xerinda, S; Marques, R; Martinez, E; Sarmento, A; Medina, JL

Background: In HIV-infected patients, combination antiretroviral therapy (cART) is associated with clinical lipodystrophy (CL) and metabolic abnormalities (MA). This study aimed to evaluate the prevalence of the metabolic syndrome (MS) and its components, and to determine whether patients with or without CL had a different prevalence of MA.Methods: We evaluated 345 HIV-infected patients on cART using two differ...


Estudo comparativo, aleatorizado, em dupla ocultação, de orlistat versus placeb...

Castro, JJ; Dias, T; Chambel, P; Carvalheiro, M; Correia, LG; Guerreiro, L; Marques, O; Medina, JL; Nobre, E; Nunes, JS; Pereira, MC; Polónia, J

INTRODUCTION: Obesity is a chronic disease and a serious health problem that leads to increased prevalence of diabetes, hypertension, dyslipidemia and gallbladder disease. OBJECTIVE: To evaluate the efficacy of orlistat for weight loss and improved lipid profile compared to placebo in obese patients with hypercholesterolemia, treated over a period of 6 months. METHODOLOGY: In a 6-month, multicenter (10 centers ...


Psychological characteristics in an obese population assessed using psychometri...

Correia, Flora; Poínhos, Rui; Pinhao, S; Bruno M P M Oliveira; Coelho, R; De Almeida, MDV; Medina, JL; Galvao Teles, A

Background and aims: For several decades, psychological characteristics associated to obesity have been discussed, and it is important to know them as they could influence the development of the disease. Aim of this study was to describe psychological characteristics of an obese sample using psychometric self-evaluation, to compare psychological characteristics between sexes, between those who had and those who...


Obstacles in dietary treatment of obesity

Correia, Flora; Pinhao, S; Poínhos, Rui; Bruno M P M Oliveira; de Almeida, MDV; Medina, JL; Galvao Teles, A

Those who work in obesity treatment know that long term success is hard to achieve. The reasons for non compliance in diet therapies are not well understood. In this study, we tried to recognize difficulties and barriers linked to unsuccessful weight reduction. This study was conducted in an outpatient clinic of a central university hospital. 442 overweight patients (371 women and 71 men), with BMI >= 25 kg/m(2...


Estudo Comparativo, Aleatorizado, em Dupla Ocultação, de Orlistat Versus Placeb...

Castro, JJ; Dias, T; Chambel, P; Carvalheiro, M; Correia, LG; Guerreiro, L; Marques, O; Medina, JL; Nobre, E; Silva Nunes, J; Pereira, MC; Polónia, J

INTRODUCTION: Obesity is a chronic disease and a serious health problem that leads to increased prevalence of diabetes, hypertension, dyslipidemia and gallbladder disease. OBJECTIVE: To evaluate the efficacy of orlistat for weight loss and improved lipid profile compared to placebo in obese patients with hypercholesterolemia, treated over a period of 6 months. METHODOLOGY: In a 6-month, multicenter (10 centers ...


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