Encontrados 13 documentos, a visualizar página 1 de 2

Prognostic role and clinicopathological features of SMAD4 gene mutation in panc...

Purpose: The prognostic value of SMAD4 in pancreatic cancer has been evaluated in several studies. However, the conclusions remain controversial. Therefore, we aimed to evaluate the prognostic value of the SMAD4 gene in pancreatic cancer to aid in the design of therapeutic strategies. Methods: This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria and the...

Prognostic role and clinicopathological features of SMAD4 gene mutation in panc...

Purpose: The prognostic value of SMAD4 in pancreatic cancer has been evaluated in several studies. However, the conclusions remain controversial. Therefore, we aimed to evaluate the prognostic value of the SMAD4 gene in pancreatic cancer to aid in the design of therapeutic strategies. Methods: This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria and the...

Modelos de sobrevivência paramétricos para acontecimentos recorrentes

Análise de Sobrevivência em R

Modelos paramétricos flexíveis para acontecimentos recorrentes

Neste trabalho, s˜ao propostas duas classes de modelos pa ram´etricos para analisar o tempo entre acontecimentos recorrentes, utilizando splines c´ubicos restritos. As classes de modelos diferem no modo como se lida com a dependˆencia entre acontecimentos. Al´em disso, ambas as classes s˜ao caracterizadas por uma transforma¸c˜ao da fun¸c˜ao de sobrevivˆencia, atrav´es da fun¸c˜ao de liga¸c˜ao log-log ou −logit....

A novel and simpler alkaline hydrolysis methodology for extraction of ferulic a...

This work aims to develop simpler methodologies of extracting ferulic acid (FA) from brewer’s spent grain (BSG). BSG is produced by brewing companies at high amounts all over the year and does not possess a direct application. Thus, its use as raw material for extraction of bioactive compounds has gained attention in the last years. FA has different interesting applications in cosmetics, food industry, and phar...

Um olhar sobre o desenvolvimento de modelos de sobrevivência para acontecimento...

Modelos de sobrevivência aplicados à análise de acontecimentos múltiplos

Na modela¸c˜ao de acontecimentos m´ultiplos, uma abor dagem muita utilizada consiste em desenvolver extens˜oes do modelo semiparam´etrico de Cox. Contudo, quando se considera que o co nhecimento da distribui¸c˜ao do tempo ´e importante para o estudo, a abordagem param´etrica revela-se mais adequada. Neste trabalho, s˜ao apresentados dois novos modelos param´etricos baseados na dis tribui¸c˜ao de Weibull (modelo...

Lipid biosignature of breast cancer tissues by matrix-assisted laser desorption...

Purpose One of the hallmarks of cancer cells is the demand of supply for the synthesis of new membranes involved in cell proliferation and lipids have an important role in cellular structure, signaling pathways and progression of cancer. In this sense, lipid studies have become an essential tool allowing the establishment of signatures associated with breast cancer (BC). In this regard, some metabolic processes...

A review of Cox' s model extensions for multiple events

In longitudinal studies, it is usual that a given subject can experience several failures. To analyse multiple failure-time data, we reviewed some extensions of Cox's regression model, which were proposed by: Prentice, Williams and Peterson (PWP); Andersen and Gill (AG); Wei, Lin e Weissfeld (WLW); and Lee, Wei and Amato (LWA). Our main goal is to underline the differences between these extensions, through a br...