2 documents found, page 1 of 1
ECM-enriched alginate hydrogels for bioartificial pancreas: an ideal niche to i...
Crisóstomo, Joana; Pereira, Ana M.; Bidarra, Sílvia J.; Gonçalves, Ana C.; Granja, Pedro L.; Coelho, Jorge Fj; Barrias, Cristina C; Seiça, RaquelIntroduction: The success of a bioartificial pancreas crucially depends on ameliorating encapsulated beta cells survival and function. By mimicking the cellular in vivo niche, the aim of this study was to develop a novel model for beta cells encapsulation capable of establishing an appropriate microenvironment that supports interactions between cells and extracellular matrix (ECM) components. Methods: ECM compo...
Advanced Biofabrication Strategies for Skin Regeneration and Repair
Pereira, Rúben F.; Barrias, Cristina C; Granja, Pedro L; Bártolo, Paulo J.Skin is the largest organ of human body, acting as a barrier with protective, immunologic and sensorial functions. Its permanent exposure to the external environment can result in different kinds of damage with loss of variable volumes of extracellular matrix. For the treatment of skin lesions, several strategies are currently available, such as the application of autografts, allografts, wound dressings and tis...