5 documents found, page 1 of 1
Estudo do potencial efeito inibitório do composto sintético CP001 sobre a quine...
Meira, Assuero SilvaPterocarpans represented the largest isoflavonoid class after isoflavones and recent studies have revealed that representatives of this group can act on specific targets of mitosis. This study evaluated the potential cytotoxic , genotoxic and mutagenic of the CP001 in tumoral and normal human cell lines. The inhibitory effect in Eg5 kinesin and quantum biochemistry calculation has been peformed as well. Cytotox...
Avaliação do autoconhecimento da equipe médica, de enfermagem e farmácia sobre ...
Souza, Antonia Amanda Lima; Néri, Eugenie Desirèe Rabelo; Gomes, Glauciene Cardoso; Lopes, Emeline Moura; Fonteles, Maria de FrançaObjetivo: determinar o grau de conhecimento sobre medicamentos potencialmente perigosos (MPP), entre médicos, equipe de enfermagem, equipe de farmácia e residentes. Método: estudo transversal e quantitativo realizado com 157 profissionais pertencentes à equipe médica, farmacêutica, de enfermagem e residentes. O estudo foi realizado em duas fases: I) avaliação do conhecimento e; II) intervenção educativa. Foram ...
Preliminary in vitro evaluation of the anti-proliferative activity of guanylhyd...
França, Paulo H. B.; Silva-Júnior, Edeildo F. da; Aquino, Pedro G. V.; Santana, Antônio E. G.; Ferro, Jamylle N. S.; Barreto, Emiliano de OliveiraGuanylhydrazones have shown promising antitumor activity in preclinical tumor models in several studies. In this study, we aimed at evaluating the cytotoxic effect of a series of synthetic guanylhydrazones. Different human tumor cell lines, by including HCT-8 (colon carcinoma), MDA-MB-435 (melanoma) and SF-295 (glioblastoma) were continuous exposed to guanylhydrazone derivatives for 72 hours and growth inhibiti...
Perfil de flavonoides e avaliação do potencial antioxidante e citotóxico de Bau...
Santos, Priscila Moraes dos; Almeida, Patrícia Danielle Oliveira de; Lima, Emerson Silva; Moraes Filho, Manoel Odorico de; Costa, Patrícia Marçal daBauhinia purpurea (Fabaceae). Plants of the Bauhinia species (Fabaceae) are used in the treatment of several infections and diseases, especially diabetes. In this paper, with an aim to contribute to the knowledge of the chemistry and therapeutic potential of the Amazonian species of the genus Bauhinia, flavonoid profiles in the leaves and branches of Bauhinia purpurea collected in Manaus and São Gabriel da Cach...
Estudo do potencial citotóxico de novos ésteres sintéticos derivados da mistura...
Meira, Assuero SilvaTriterpenoids are compounds that in recent years have aroused considerable interest because of their structural diversity and the discovery of a broad spectrum of pharmacological activities. This study evaluated the cytotoxic potential of four derivatives of a mixture of α-, β-amyrin in human tumor cell lines. Among these, only compound 3-O-α-Carboximaleinato of, β-amyrin (3a/3b) was active, especially in the l...