4 documents found, page 1 of 1
PEDOT:PSS-coated polybenzimidazole electroconductive nanofibers for biomedical ...
Sordini, Laura; Silva, João C.; Garrudo, Fábio F. F.; Rodrigues, Carlos A. V.; Marques, Ana C.; Linhardt, Robert J.; Cabral, Joaquim S. M.Bioelectricity drives several processes in the human body. The development of new materials that can deliver electrical stimuli is gaining increasing attention in the field of tissue engineering. In this work, novel, highly electrically conductive nanofibers made of poly [2,20 - m-(phenylene)-5,50 -bibenzimidazole] (PBI) have been manufactured by electrospinning and then coated with cross-linked poly (3,4-ethyl...
Effects of glycosaminoglycan supplementation in the chondrogenic differentiatio...
Silva, João C.; Moura, Carla; Matos, António P. Alves de; Cabral, Joaquim M. S.; Linhardt, Robert J.; Ferreira, Frederico CasteloThe lack of effective and long-term treatments for articular cartilage defects has increased the interest for innovative tissue engineering strategies. Such approaches, combining cells, biomaterial matrices and external biochemical/physical cues, hold promise for generating fully functional cartilage tissue. Herein, this study aims at exploring the use of the major cartilage glycosaminoglycans (GAGs), chondroit...
Extruded bioreactor perfusion culture supports the chondrogenic differentiation...
Silva, João C.; Moura, Carla; Borrecho, Gonçalo; Matos, António P. Alves de; Silva, Cláudia L. da; Cabral, Joaquim M. S.; Bártolo, Paulo J.Novel bioengineering strategies for the ex vivo fabrication of native-like tissue-engineered cartilage are crucial for the translation of these approaches to clinically manage highly prevalent and debilitating joint diseases. Bioreactors that provide different biophysical stimuli have been used in tissue engineering approaches aimed at enhancing the quality of the cartilage tissue generated. However, such syste...
Extracellular matrix decorated polycaprolactone scaffolds for improved mesenchy...
Silva, João C.; Carvalho, Marta S.; Udangawa, Ranodhi N.; Moura, Carla; Cabral, Joaquim M. S.; Silva, Cláudia L. da; Ferreira, Frederico CasteloThe clinical demand for tissue-engineered bone is growing due to the increase of non-union fractures and delayed healing in an aging population. Herein, we present a method combining additive manufacturing (AM) techniques with cell-derived extracellular matrix (ECM) to generate structurally well-defined bioactive scaffolds for bone tissue engineering (BTE). In this work, highly porous three-dimensional polycapr...