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Detection of anti-infliximab antibodies is impacted by antibody titer, inflixim...

Afonso, Joana; Lopes, Susana; Gonçalves, Raquel; Caldeira, Paulo; Lago, Paula; Sousa, Helena Tavares; Ramos, Jaime; Gonçalves, Ana Rita; Ministro, Paula

Background: There is scant information on the accuracy of different assays used to measure anti-infliximab antibodies (ADAs), especially in the presence of detectable infliximab (IFX). We thus aimed to evaluate and compare three different assays for the detection of IFX and ADAs and to clarify the impact of the presence of circulating IFX on the accuracy of the ADA assays.Methods: Blood samples from 79 ulcerati...


Oral mucosa lesions and oral symptoms in inflammatory bowel disease patients

Laranjeira, Nuno; Fonseca, Jorge; Meira, Tânia; Freitas, João; Valido, Sara; Leitão, Jorge

"Background - Inflammatory Bowel Disease is known for its extra intestinal manifestations, the oral cavity is no exception. Objectives - The aim of this study was to evaluate the association between Inflammatory Bowel Disease and oral mucosa lesions and symptoms, and complementary to evaluate their possible relation with oral hygiene, smoking habits, drug therapy, duration and activity of the disease. Methods -...


Manifestações orais em doentes com doença inflamatória intestinal: estudo piloto

Laranjeira, Nuno; Valido, Sara; Meira, Tânia; Fonseca, Jorge; Freitas, João

Introdução: A doença inflamatória intestinal (DII), incluíndo a doença de Crohn (DC) e a colite ulcerosa (CU), apresenta manifestações orais descritas desde 1969.


Manifestações orais em doentes com doença inflamatória intestinal. Estudo piloto

Laranjeira, Nuno; Valido, Sara; Meira, Tânia; Fonseca, Jorge; Freitas, João

"Introdução: A doença inflamatória intestinal (DII), incluíndo a doença de Crohn (DC) e a colite ulcerosa (CU), apresenta manifestações orais descritas desde 1969. Objectivos: O presente estudo pretende, em doentes com DII: identificar, caracterizar e quantificar as lesões da mucosa oral; avaliar a presença e gravidade de doença periodontal; avaliar a presença e gravidade de cárie dentária; verificar uma possív...


Ostomy metastasis after pull endoscopic gastrostomy: a unique favorable outcome

Fonseca, Jorge; Adriana, Carla; Fróis-Borges, Miguel; Meira, Tânia; Oliveira, Gabriel; Santos, José Carlos

Head and neck cancer (HNC) patients tend to develop dysphagia. In order to preserve the nutritional support, many undergo endoscopic gastrostomy (PEG). In HNC patients, ostomy metastasis is considered a rare complication of PEG, but there are no reports of successful treatment of these metastatic cancers. We report the case of a 65 years old pharyngeal/laryngeal cancer patient who underwent a PEG before the nec...


Oral mucosa lesions and oral symptoms in inflammatory bowel disease patients

Laranjeira, Nuno; Fonseca, Jorge; Meira, Tânia; Freitas, João; Valido, Sara; Leitão, Jorge

Background - Infammatory Bowel Disease is known for its extra intestinal manifestations, the oral cavity is no exception. Objectives - The aim of this study was to evaluate the association between Infammatory Bowel Disease and oral mucosa lesions and symptoms, and complementary to evaluate their possible relation with oral hygiene, smoking habits, drug therapy, duration and activity of the disease. Methods - Pa...


Bleeding and starving: fasting and delayed refeeding after upper gastrointestin...

Fonseca, Jorge; Meira, Tânia; Nunes, Ana; Santos, Carla Adriana

"Context - Early refeeding after nonvariceal upper gastrointestinal bleeding is safe and reduces hospital stay/costs. Objective - The aim of this study was obtaining objective data on refeeding after nonvariceal upper gastrointestinal bleeding. Methods - From 1 year span records of nonvariceal upper gastrointestinal bleeding patients that underwent urgent endoscopy: clinical features; rockall score; endoscopic ...


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