5 documents found, page 1 of 1
The role of the hippocampal CA2 area in social memory
Meira, Torcato Duarte NovoDeclarative memory is a subtype of long-term memory that is expressed by a deliberate and conscious retrieval of our store of knowledge of people, places, objects and events. It is mediated through three distinct phases: memory encoding, consolidation and recall. Due to its complexity, a key approach to understand declarative memory is to study the participation of the different subregions of the hippocampal fo...
Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocam...
Vaz-Silva, João; Gomes, Patrícia; Jin, Qi; Zhu, Mei; Zhuravleva, Viktoriya; Quintremil, Sebastian; Meira, Torcato Duarte Novo; Silva, JoanaEmerging studies implicate Tau as an essential mediator of neuronal atrophy and cognitive impairment in Alzheimer's disease (AD), yet the factors that precipitate Tau dysfunction in AD are poorly understood. Chronic environmental stress and elevated glucocorticoids (GC), the major stress hormones, are associated with increased risk of AD and have been shown to trigger intracellular Tau accumulation and downstre...
A circuit from hippocampal CA2 to lateral septum disinhibits social aggression
Leroy, Felix; Park, Jung; Asok, Arun; Brann, David H; Meira, Torcato Duarte Novo; Boyle, Lara M; Buss, Eric W; Kandel, Eric R; Siegelbaum, Steven AAlthough the hippocampus is known to be important for declarative memory, it is less clear how hippocampal output regulates motivated behaviours, such as social aggression. Here we report that pyramidal neurons in the CA2 region of the hippocampus, which are important for social memory, promote social aggression in mice. This action depends on output from CA2 to the lateral septum, which is selectively enhanced...
A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social mem...
Meira, Torcato Duarte Novo; Leroy, Felix; Buss, Eric W.; Oliva, Azahara; Park, Jung; Siegelbaum, Steven A.Recent results suggest that social memory requires the dorsal hippocampal CA2 region as well as a subset of ventral CA1 neurons. However, it is unclear whether dorsal CA2 and ventral CA1 represent parallel or sequential circuits. Moreover, because evidence implicating CA2 in social memory comes largely from long-term inactivation experiments, the dynamic role of CA2 in social memory remains unclear. Here, we us...
Input-timing-dependent plasticity in the hippocampal CA2 region and its potenti...
Leroy, Felix; Brann, David H.; Meira, Torcato Duarte Novo; Siegelbaum, Steven A.Input-timing-dependent plasticity (ITDP) is a circuit-based synaptic learning rule by which paired activation of entorhinal cortical (EC) and Schaffer collateral (SC) inputs to hippocampal CA1 pyramidal neurons (PNs) produces a long-term enhancement of SC excitation. We now find that paired stimulation of EC and SC inputs also induces ITDP of SC excitation of CA2 PNs. However, whereas CA1 ITDP results from long...