9 documents found, page 1 of 1

Prescrição de Benzodiazepinas e Outros Sedativos na Administração Regional de S...

Introduction: Among the Organization for Economic Co-operation and Development members, Portugal has the highest reported consumption of anxiolytics, hypnotics, and sedatives, of which a large proportion are benzodiazepines or related drugs. These are known to cause tolerance and dependence. Other drugs with hypnotic effect, such as antidepressants, antihistamines, antipsychotics, or anticonvulsants have been i...

The pro-proliferative effect of insulin in human breast epithelial DMBA-transfo...

Type 2 diabetes mellitus (T2DM) is linked to an increased risk of breast cancer. We aimed to investigate how T2DM-associated characteristics (high levels of glucose, insulin, leptin, inflammatory mediators and oxidative stress) influence breast cancer carcinogenesis, in DMBA-treated (MCF-12ADMBA) and non-treated breast epithelial (MCF-12A) cell lines. Insulin (50 nM) promotes cell proliferation, 3H-DG uptake an...

Biocompatibility of the biopolymer cyanoflan for applications in skin wound hea...

There is a great demand for the development of novel wound dressings to overcome the time and costs of wound care performed by a vast number of clinicians, especially in the current overburdened healthcare systems. In this study, Cyanoflan, a biopolymer secreted by a marine unicellular cyanobacterium, was evaluated as a potential biomaterial for wound healing. Cyanoflan effects on cell viability, apoptosis, and...

Therapeutic challenge of a paediatric case of Graves' disease with severe ophth...

Thymic epithelial cells require p53 to support their long-term function in thym...

Thymic epithelial cells (TECs) provide crucial microenvironments for T-cell development and tolerance induction. As the regular function of the thymus declines with age, it is of fundamental and clinical relevance to decipher new determinants that control TEC homeostasis in vivo. Beyond its recognized tumor suppressive function, p53 controls several immunoregulatory pathways. To study the cell-autonomous role o...

Thymic crosstalk restrains the pool of cortical thymic epithelial cells with pr...

Cortical (cTEC) and medullary (mTEC) thymic epithelial cells establish key microenvironments for T-cell differentiation and arise from thymic epithelial cell progenitors (TEP). However, the nature of TEPs and the mechanism controlling their stemness in the postnatal thymus remain poorly defined. Using TEC clonogenic assays as a surrogate to survey TEP activity, we found that a fraction of cTECs generates specia...

Intermediate expression of CCRL1 reveals novel subpopulations of medullary thym...

Cortical and medullary thymic epithelial cells (cTECs and mTECs, respectively) provide inductive microenvironments for T-cell development and selection. The differentiation pathway of cTEC/mTEC lineages downstream of common bipotent progenitors at discrete stages of development remains unresolved. Using IL-7/CCRL1 dual reporter mice that identify specialized TEC subsets, we show that the stepwise acquisition of...

Autoimmune Thyroiditis Presenting as Palmoplantar Keratoderma

Palmoplantar keratoderma is a heterogeneous group of hereditary and acquired disorders characterized by abnormal thickening of palms and soles. Hypothyroidism is an unusual cause of palmoplantar keratoderma, rarely reported in the literature. We report a case of a 43-year-old woman presented with a 3-month history of a diffuse palmoplantar hyperkeratosis unresponsive to topical keratolytics and corticosteroids....

Diarreia de Causa Particular num Indivíduo Imunocompetente?

A colite a citomegalovírus em imunocompetentes é rara. Existe evidência que causa morbilidade e mortalidade nos imunocomprometidos. Os autores descrevem o caso de uma doente de 75 anos, admitida por diarreia com sangue, com 4 semanas de evolução com antecedentes de Diabetes Mellitus, Insuficiência cardíaca e renal crónica. Ao exame objectivo apresentava-se descorada, desidratada, hipotensa, com insuficiência ca...