2 documents found, page 1 of 1
Loss of 5 '-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade ...
Menezes, Weder Pereira de; Oliveira Silva, Viviane Aline; Faria Gomes, Izabela Natalia; Rosa, Marcela Nunes; Corcoll Spina, Maria LuisaMade available in DSpace on 2020-12-10T19:54:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Barretos Cancer Hospital; Public Ministry of Labor Campinas (Research, Prevention and Education of Occ...
AKT can modulate the in vitro response of HNSCC cells to irreversible EGFR inhi...
Silva-Oliveira, Renato José; Melendez, Matias; Martinho, Olga; Zanon, Maicon F.; Viana, Luciano de Souza; Carvalho, André Lopes; Reis, R. M.Epidermal growth factor receptor (EGFR) is overexpressed in up to 90% of head and neck squamous cell carcinoma (HNSCC) tumors. Cetuximab is the first targeted (anti-EGFR) therapy approved for the treatment of HNSCC patients. However, its efficacy is limited due to primary and secondary resistance, and there is no predict biomarkers of response. New generation of EGFR inhibitors with pan HER targeting and irreve...