4 documents found, page 1 of 1
Biological evaluation of new diarylpentanoid analogues for antitumor activity
Castro, E.; Moreira, J.; Silva, P. M. A.; Saraiva , L.; Pinto, M.; Bousbaa, Hassan; Cidade, H.Background: Cancer is associated with high mortality rates and its incidence worldwide is increasing significantly [1]. Several therapeutic strategies have been used in cancer therapy such as microtu-bule-targeting agents [2]. However, these drugs are highly toxic and are associated with high tumor resistance, making their long-term use unfeasible [3,4]. Therefore, new small molecules that can overcome the disa...
Norhierridin B, a new hierridin B-based hydroquinone with improved antiprolifer...
Brandão, P.; Moreira, J.; Almeida, J.; Nazareth, N.; Sampaio-Dias, I.E.; Vasconcelos, V.; Martins, R.; Leão, P.; Pinto, M.; Saraíva, L.; Cidade, H.Hierridin B (6), a methylated hydroquinone isolated from the marine picocyanobacterium Cyanobium sp. LEGE 06113, moderately inhibited the growth of colon adenocarcinoma HT-29 cells. Aiming to improve the potential antitumor activity of this natural product, the demethylated analogue, norhierridin B (10), as well as its structurally-related quinone (9), were synthesized and evaluated for their growth inhibitory ...
Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor acti...
Pinto, P.; Machado, C.M.; Moreira, J.; Almeida, J.D.P.; Silva, P.M.A.; Henriques, A.C.; Soares, J.X.; Salvador, J.A.R.; Afonso, C.; Pinto, M.This study describes the synthesis of a series of chalcones, including pyrazole and a,b-epoxide de- rivatives, and evaluation of their cell growth inhibitory activity in three human tumor cell lines, as well as their lipophilicity using liposomes as a biomimetic membrane model. Structure-activity and structure- lipophilicity relationships were established for the synthetized chalcones. From this work, nine chal...
Potential of synthetic chalcone derivatives to prevent marine biofouling
Almeida, J.R.; Moreira, J.; Pereira, D.; Pereira, S.; Antunes, J.; Palmeira, A.; Vasconcelos, V.; Pinto, M.; Correia-da-Silva, M.; Cidade, H.Biofouling represents a major economic, environmental and health concern for which new eco-friendly solutions are needed. International legislation has restricted the use of biocidal-based antifouling coatings, and increasing efforts have been applied in the search for environmentally friendly antifouling agents. This research work deals with the assessment of the interest of a series of synthetic chalcone deri...