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Diagnosis of tuberculosis: a consensus statement from the Brazilian Thoracic As...
Silva,Denise Rossato; Rabahi,Marcelo Fouad; Sant’Anna,Clemax Couto; Silva-Junior,José Laerte Rodrigues da; Capone,Domenico; Bombarda,SidneyABSTRACT Early, accurate diagnosis of tuberculosis is one of the major pillars of the control of the disease. The purpose of this consensus statement is to provide health professionals with the most current, useful evidence for the diagnosis of tuberculosis in Brazil. To that end, the Tuberculosis Committee of the Brazilian Thoracic Association brought together 14 members of the Association with recognized expe...
Tuberculosis and COVID-19, the new cursed duet: what differs between Brazil and...
Silva,Denise Rossato; Mello,Fernanda Carvalho de Queiroz; D’Ambrosio,Lia; Centis,Rosella; Dalcolmo,Margareth Pretti; Migliori,Giovanni BattistaABSTRACT On April 1st, 2020, COVID-19 surpassed tuberculosis regarding the number of deaths per day worldwide. The combination of tuberculosis and COVID-19 has great potential for morbidity and mortality. In addition, the COVID-19 pandemic has had a significant impact on the diagnosis and treatment of tuberculosis. In this review article, we address concurrent tuberculosis and COVID-19, with particular regard t...
Rapid detection of Mycobacterium tuberculosis in children using blood and urine...
Costa-Lima,Juliana Figueirêdo da; Pimentel,Lílian Maria Lapa Montenegro; Santos,Fabiana Cristina Fulco; Salazar,Marcela Pereira; Duarte,Rafael SilvaAbstract INTRODUCTION: Laboratory and clinical features of childhood tuberculosis (TB) are non-specific and establishing an accurate diagnosis remains a challenge. This study evaluated a Single tube nested-PCR (STNPCR) to detect genomic DNA of Mycobacterium tuberculosis complex in blood and urine. METHODS: Biological samples were obtained from children (<15 years old) with clinical suspicion of pulmonary and ex...
Detection of Drug Resistant Mycobacterium Tuberculosis Strains Using Kit SIRE N...
Miranda,Silvana Spindola de; Almeida,Isabela Neves de; Mansur,Maria de Fátima Filardi Oliveira; Figueredo,Lida Jouca de Assis; Carvalho,Wânia da SilvaAbstract (1) Background: The Commercial Kit SIRE Nitratase® PlastLabor, is a drug susceptibility test kit used to detect Mycobacterium tuberculosis resistance to first-line TB treatment drugs. The present study aimed at evaluating its performance in a multicenter study. (2) Methods: To determine its accuracy, the proportion methods in Lowenstein Jensen medium or the BACTECTMMGITTM960 system was used as a gold s...
Spirometry results after treatment for pulmonary tuberculosis: comparison betwe...
Mancuzo,Eliane Viana; Martins Netto,Eduardo; Sulmonett,Nara; Viana,Vanessa de Souza; Croda,Júlio; Kritski,Afranio LineuABSTRACT Objective: To compare patients with and without previous lung disease, in terms of the spirometry results after they had been treated for pulmonary tuberculosis (PTB) and cured, as well as to analyze risk factors related to functional severity. Methods: This was a cross-sectional, multicenter study conducted at four referral centers in Brazil. Patients were divided into two groups: those with a history...
Shortened tuberculosis treatment regimens: what is new?
Silva,Denise Rossato; Mello,Fernanda Carvalho de Queiroz; Migliori,Giovanni BattistaABSTRACT Given the global burden of tuberculosis, shortened treatment regimens with existing or repurposed drugs are needed to contribute to tuberculosis control. The long duration of treatment of drug-susceptible tuberculosis (DS-TB) is associated with nonadherence and loss to follow up, and the treatment success rate of multidrug-resistant tuberculosis (MDR-TB) is low (approximately 50%) with longer regimens....
Using the No-Apnea score to screen for obstructive sleep apnea in adults referr...
Duarte,Ricardo Luiz de Menezes; Silveira,Flavio José Magalhães da; Sá,Tiago Soares de Oliveira e; Rabahi,Marcelo FouadABSTRACT Objective: To evaluate the performance of the No-Apnea score, a simplified screening instrument for obstructive sleep apnea (OSA), by gender. Methods: This was a cross-sectional study including adults undergoing full polysomnography. The No-Apnea model comprises two items (neck circumference and age) with a total score of 0 to 9. The severity of OSA was categorized, on the basis of the apnea-hypopnea i...
Características clínicas e epidemiológicas de casos de infecção pulmonar por My...
Goldenberg,Telma; Gayoso,Regina; Mogami,Roberto; Lourenço,Maria Cristina; Ramos,Jesus Paes; Carvalho,Luciana Distasio de; Dalcolmo,Margareth PrettiRESUMO Objetivo Avaliar características clínicas, tomográficas e microbiológicas dos pacientes com doença pulmonar causada pela M. kansasii (DPMK) atendidos em unidade ambulatorial no período 2006-2016. Métodos Estudo descritivo, em que foram analisados 38 pacientes. Foram analisadas as características demográficas, clínico-radiológicas, laboratoriais e terapêuticas. Resultados A média de idade foi 64 anos (DP=...
The Impact of Lung Carcinoma Histology on the Frequency of Bone Metastases
Oliveira,Marcelo Bragança dos Reis; Souza,Larissa Costa; Sampayo,Ermides Javier Garcia; Carvalho,Gustavo Sobral de; Mello,Fernanda Carvalho de QueirozAbstract Objective Lung cancer is the leading cause of death by cancer, and the bones are one of the most common sites of metastasis from this condition. This study aimed to evaluate the influence of lung carcinoma histology on the frequency of bone metastases. Methods This retrospective study evaluated the medical records of 407 patients diagnosed with lung cancer between 2003 and 2012. The prevalence of bone ...
Latent tuberculosis infection in patients with rheumatic diseases
Anton,Camila; Machado,Felipe Dominguez; Ramirez,Jorge Mario Ahumada; Bernardi,Rafaela Manzoni; Palominos,Penélope Esther; Brenol,Claiton ViegasABSTRACT Most people infected by Mycobacterium tuberculosis (Mtb) do not have any signs or disease symptoms, a condition known as latent tuberculosis infection (LTBI). The introduction of biological agents, mainly tumor necrosis factor (TNF) inhibitors, for the treatment of immune-mediated diseases such as Rheumatoid Arthritis (RA) and other rheumatic diseases, increased the risk of reactivation of LTBI, leadin...