4 documents found, page 1 of 1
The use of the anticoagulant heparin and corticosteroid dexamethasone as promin...
Melo, Heloísa Antoniella Braz de; Faria, Sara Socorro; Nascimento, Gabriel Pasquarelli do; Santos, Igor de Oliveira; Kobinger, Gary P.COVID-19 is spreading worldwide at disturbing rates, overwhelming global healthcare. Mounting death cases due to disease complications highlight the necessity of describing efficient drug therapy strategies for severe patients. COVID-19 severity associates with hypercoagulation and exacerbated inflammation, both influenced by ACE2 downregulation and cytokine storm occurrence. In this review, we discuss the appl...
Potencial efeito neuroprotetor, imunomodulador e antiviral do ômega-3 (DHA) na ...
Melo, Heloísa Antoniella Braz deDissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Patologia Molecular, 2021.; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) e Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).; O vírus Zika (ZIKV) possui um intenso tropismo por células neurais e tem sido correlacionado com o desenvolvimento agravos neurológicos pós-infe...
Potential neuroprotective and antiinfammatory efects provided by omega-3 (DHA) ...
Melo, Heloísa Antoniella Braz de; Nascimento, Gabriel Pasquarelli do; Corrêa, Rafael; Almeida, Raquel das Neves; Santos, Igor de OliveiraZika virus (ZIKV) has a strong tropism for the nervous system and has been related to post-infection neurological syndromes. Once neuronal cells are infected, the virus is capable of modulating cell metabolism, leading to neurotoxicity and cellular death. The negative efect of ZIKV in neuron cells has been characterized. However, the description of molecules capable of reversing these cytotoxic efects is still ...
Hypercoagulopathy and adipose tissue exacerbated inflammation may explain highe...
Nascimento, Gabriel Pasquarelli do; Melo, Heloísa Antoniella Braz de; Faria, Sara Socorro; Santos, Igor de Oliveira; Kobinger, Gary P.COVID-19, caused by SARS-CoV-2, is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Several reports from around the world have identified obesity and severe obesity as one of the strongest risk factors for COVID-19 hospitalization and mechanical ventilation. Moreover, countries with greater obesity prevalence have a higher morbidity and mortality risk of developing serious ou...